UBR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032007Biological processnegative regulation of TOR signaling
GO_0016567Biological processprotein ubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0071596Biological processubiquitin-dependent protein catabolic process via the N-end rule pathway
GO_0071233Biological processcellular response to L-leucine
GO_0000502Cellular componentproteasome complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0070728Molecular functionL-leucine binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameUBR1
Protein nameAlternative protein UBR1
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)
E3 ubiquitin-protein ligase (EC 2.3.2.27)
Ubiquitin protein ligase E3 component n-recognin 1
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

AccessionsH3BUZ4
H3BQF8
ENST00000569971.5
ENST00000290650.9 [Q8IWV7-1]
H3BS20
L8E998
ENST00000563239.1
H3BUC4
A0A0C4DGM0
Q8IWV7
ENST00000627960.1
ENST00000569066.2
A0A087WTJ9
ENST00000546274.6
ENST00000569243.5
ENST00000569337.1
H3BNQ6
ENST00000564540.5