UBE2V2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006282Biological processregulation of DNA repair
GO_0016567Biological processprotein ubiquitination
GO_0000729Biological processDNA double-strand break processing
GO_0042275Biological processerror-free postreplication DNA repair
GO_0000209Biological processprotein polyubiquitination
GO_0006301Biological processpostreplication repair
GO_2000781Biological processpositive regulation of double-strand break repair
GO_1902523Biological processpositive regulation of protein K63-linked ubiquitination
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0031372Cellular componentUBC13-MMS2 complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2V2
Protein nameUbiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Ubiquitin conjugating enzyme E2 V2
Ubiquitin-conjugating enzyme E2 variant 2
SynonymshCG_1640505
MMS2
UEV2
DescriptionFUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. .

FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. .

FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. .

AccessionsENST00000520595.2
ENST00000517630.5
H0YBX6
ENST00000521346.5
A0M8W4
G3V113
E5RIF1
ENST00000518360.5
ENST00000523111.7
Q15819