UBE2S report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070979Biological processprotein K11-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051301Biological processcell division
GO_0010994Biological processfree ubiquitin chain polymerization
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0010458Biological processexit from mitosis
GO_0036211Biological processprotein modification process
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0010997Molecular functionanaphase-promoting complex binding

IV. Literature review

[source]
Gene nameUBE2S
Protein nameUbiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Ubiquitin conjugating enzyme E2 S
SynonymsOK/SW-cl.73
E2EPF
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit . Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A . In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination . .

AccessionsENST00000587845.5
Q6NXQ4
ENST00000264552.14
ENST00000589978.1
K7EPJ1
K7EM75
Q16763