TUT7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001556Biological processoocyte maturation
GO_0071044Biological processhistone mRNA catabolic process
GO_0031054Biological processpre-miRNA processing
GO_0071076Biological processRNA 3' uridylation
GO_1990074Biological processpolyuridylation-dependent mRNA catabolic process
GO_0010586Biological processmiRNA metabolic process
GO_0031123Biological processRNA 3'-end processing
GO_0141008Biological processretrotransposon silencing by mRNA destabilization
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0050265Molecular functionRNA uridylyltransferase activity
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0070569Molecular functionuridylyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTUT7
Protein nameTerminal uridylyl transferase 7
ZCCHC6 protein
Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)
RNA uridylyltransferase (EC 2.7.7.52)
SynonymsZCCHC6
KIAA1711
HS2
DescriptionFUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay . Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets . Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms . Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A . In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing . Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species . Does not play a role in replication-dependent histone mRNA degradation . Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult . TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules . .

AccessionsENST00000375960.6 [Q5VYS8-4]
X6R3Q3
ENST00000375957.5
Q5VYT0
ENST00000375947.1
ENST00000277141.10
ENST00000375963.8 [Q5VYS8-1]
Q5VYS8
Q5VYS9
ENST00000375948.2
A0A0C4DFW3
Q96KX5