TRIM38 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0000209Biological processprotein polyubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0032880Biological processregulation of protein localization
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0045070Biological processpositive regulation of viral genome replication
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0050687Biological processnegative regulation of defense response to virus
GO_0032648Biological processregulation of interferon-beta production
GO_0046596Biological processregulation of viral entry into host cell
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005575Cellular componentcellular_component
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM38
Protein nameE3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)
SynonymsRNF15
RORET
DescriptionFUNCTION: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity . Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling . Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters . .

AccessionsENST00000357085.5
O00635