TRAK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050772Biological processpositive regulation of axonogenesis
GO_0048813Biological processdendrite morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048311Biological processmitochondrion distribution
GO_0006605Biological processprotein targeting
GO_0098957Biological processanterograde axonal transport of mitochondrion
GO_0022008Biological processneurogenesis
GO_0008333Biological processendosome to lysosome transport
GO_0006493Biological processprotein O-linked glycosylation
GO_0047496Biological processvesicle transport along microtubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0031966Cellular componentmitochondrial membrane
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0044295Cellular componentaxonal growth cone
GO_0005737Cellular componentcytoplasm
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_0030911Molecular functionTPR domain binding
GO_0050811Molecular functionGABA receptor binding
GO_0017022Molecular functionmyosin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAK1
Protein nameTrafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)
Trafficking kinesin protein 1
Trafficking kinesin protein 1 (Trafficking protein, kinesin binding 1, isoform CRA_c)
SynonymshCG_2000014
OIP106
KIAA1042
DescriptionFUNCTION: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors . Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes . TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). .

AccessionsENST00000484786.5
A0A5F9ZH95
C9JC32
ENST00000487159.5
A0A5F9ZI06
H7C3T3
Q9UPV9
F8WDH2
A0A0D9SFL5
ENST00000341421.7 [Q9UPV9-2]
ENST00000327628.10 [Q9UPV9-1]
ENST00000449246.5 [Q9UPV9-3]
A0A087X0N0
A0A0D9SGH2
ENST00000613405.4
ENST00000418790.5
ENST00000427771.1
ENST00000396175.5
ENST00000673621.2
ENST00000672026.1