TP73 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TP73 at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060044Biological processnegative regulation of cardiac muscle cell proliferation
GO_0006974Biological processDNA damage response
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0001822Biological processkidney development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0051262Biological processprotein tetramerization
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1901248Biological processpositive regulation of lung ciliated cell differentiation
GO_0007346Biological processregulation of mitotic cell cycle
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0010243Biological processresponse to organonitrogen compound
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0006298Biological processmismatch repair
GO_0043065Biological processpositive regulation of apoptotic process
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030054Cellular componentcell junction
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTP73
Protein nameCellular tumor antigen p53
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
DeltaN p73 (Transcription factor DNp73)
SynonymshDNp73
P73
hCG_19088
DescriptionFUNCTION: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation . .

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. .

AccessionsENST00000354437.8 [O15350-2]
Q8WXG0
ENST00000378280.5
ENST00000604479.5 [O15350-6]
ENST00000378290.4 [O15350-11]
ENST00000378285.5 [O15350-9]
O15350
ENST00000357733.7 [O15350-13]
ENST00000604074.5 [O15350-4]
ENST00000603362.5 [O15350-13]
A0A0C4DFW9
ENST00000378288.8 [O15350-8]
ENST00000378295.9 [O15350-1]
ENST00000346387.8 [O15350-6]