TOX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0010976Biological processpositive regulation of neuron projection development
GO_0001779Biological processnatural killer cell differentiation
GO_0002364Biological processNK T cell lineage commitment
GO_0043375Biological processCD8-positive, alpha-beta T cell lineage commitment
GO_0048535Biological processlymph node development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043373Biological processCD4-positive, alpha-beta T cell lineage commitment
GO_0048541Biological processPeyer's patch development
GO_0032825Biological processpositive regulation of natural killer cell differentiation
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_1902232Biological processregulation of positive thymic T cell selection
GO_0002362Biological processCD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO_0002521Biological processleukocyte differentiation
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTOX
Protein nameThymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX)
SynonymsKIAA0808
DescriptionFUNCTION: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). .

AccessionsENST00000361421.2
O94900