TMEM259 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	24% ± 7%	Explore
B cell	12 studies	24% ± 8%	Explore
fibroblast	12 studies	21% ± 6%	Explore
T cell	10 studies	21% ± 5%	Explore
macrophage	10 studies	25% ± 8%	Explore
natural killer cell	9 studies	24% ± 8%	Explore
astrocyte	9 studies	24% ± 10%	Explore
type I pneumocyte	8 studies	25% ± 6%	Explore
ciliated cell	8 studies	25% ± 10%	Explore
microglial cell	8 studies	20% ± 4%	Explore
pericyte	8 studies	22% ± 3%	Explore
epithelial cell	8 studies	37% ± 18%	Explore
CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
classical monocyte	7 studies	26% ± 13%	Explore
endothelial cell of lymphatic vessel	6 studies	23% ± 6%	Explore
smooth muscle cell	6 studies	19% ± 4%	Explore
capillary endothelial cell	6 studies	17% ± 2%	Explore
adipocyte	6 studies	28% ± 12%	Explore
basal cell	6 studies	30% ± 10%	Explore
oligodendrocyte	6 studies	25% ± 7%	Explore
plasmacytoid dendritic cell	6 studies	20% ± 5%	Explore
monocyte	5 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	24% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	20% ± 7%	Explore
glutamatergic neuron	5 studies	33% ± 20%	Explore
myofibroblast cell	5 studies	24% ± 6%	Explore
memory B cell	5 studies	18% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	26% ± 6%	Explore
goblet cell	5 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	17% ± 2%	Explore
secretory cell	4 studies	23% ± 4%	Explore
leukocyte	4 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	4 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	30% ± 14%	Explore
mature NK T cell	4 studies	22% ± 6%	Explore
neuron	4 studies	29% ± 9%	Explore
myeloid cell	4 studies	29% ± 6%	Explore
lymphocyte	4 studies	24% ± 7%	Explore
naive B cell	4 studies	19% ± 3%	Explore
vein endothelial cell	4 studies	22% ± 9%	Explore
hepatocyte	4 studies	33% ± 16%	Explore
GABAergic neuron	4 studies	33% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 5%	Explore
respiratory goblet cell	3 studies	22% ± 5%	Explore
conventional dendritic cell	3 studies	35% ± 24%	Explore
non-classical monocyte	3 studies	37% ± 15%	Explore
retinal ganglion cell	3 studies	35% ± 14%	Explore
squamous epithelial cell	3 studies	39% ± 19%	Explore
retinal pigment epithelial cell	3 studies	31% ± 10%	Explore
cardiac muscle cell	3 studies	17% ± 1%	Explore
regulatory T cell	3 studies	19% ± 5%	Explore
endothelial cell of artery	3 studies	18% ± 2%	Explore
type II pneumocyte	3 studies	26% ± 5%	Explore
dendritic cell	3 studies	38% ± 20%	Explore
abnormal cell	3 studies	28% ± 5%	Explore
endothelial cell of vascular tree	3 studies	20% ± 5%	Explore
gamma-delta T cell	3 studies	28% ± 10%	Explore
interneuron	3 studies	29% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	22% ± 6%	Explore
brain	7 studies	29% ± 14%	Explore
eye	6 studies	21% ± 7%	Explore
liver	5 studies	22% ± 8%	Explore
peripheral blood	4 studies	32% ± 12%	Explore
intestine	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	10507.78	1445 / 1445	100%	76.86	183 / 183
pancreas	100%	7525.22	328 / 328	100%	87.78	178 / 178
uterus	100%	12504.91	170 / 170	100%	83.28	458 / 459
ovary	100%	11008.52	180 / 180	100%	66.57	429 / 430
thymus	100%	15588.25	653 / 653	100%	84.93	603 / 605
intestine	100%	12598.35	966 / 966	100%	88.52	525 / 527
adrenal gland	100%	11835.66	258 / 258	100%	107.95	229 / 230
kidney	100%	11799.53	89 / 89	99%	70.91	896 / 901
prostate	100%	14420.22	245 / 245	99%	88.65	499 / 502
skin	100%	10906.66	1809 / 1809	99%	85.56	469 / 472
brain	99%	7574.03	2624 / 2642	100%	98.48	705 / 705
stomach	100%	9373.23	359 / 359	99%	79.86	284 / 286
liver	100%	9279.46	226 / 226	99%	68.28	402 / 406
lung	100%	13862.89	578 / 578	99%	71.84	1143 / 1155
bladder	100%	10831.76	21 / 21	99%	88.23	498 / 504
breast	100%	12379.45	459 / 459	99%	58.45	1104 / 1118
adipose	100%	11642.41	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	82.80	80 / 80
lymph node	0%	0	0 / 0	100%	87.86	29 / 29
spleen	100%	20754.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	88.24	45 / 45
ureter	0%	0	0 / 0	100%	114.02	1 / 1
blood vessel	100%	9593.36	1334 / 1335	0%	0	0 / 0
heart	100%	8457.12	857 / 861	0%	0	0 / 0
muscle	100%	6586.28	799 / 803	0%	0	0 / 0
peripheral blood	98%	8742.43	915 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_1904294	Biological process	positive regulation of ERAD pathway
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane

IV. Literature review

[source]

Gene name	TMEM259
Protein name	Membralin (Transmembrane protein 259) Transmembrane protein 259
Synonyms	C19orf6
Description	FUNCTION: May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. .
Accessions	ENST00000586285.2 Q4ZIN3 ENST00000356663.8 [Q4ZIN3-1] U3KQQ5 ENST00000586250.1 U3KPU1 U3KPY4 A0A0A0MTU3 ENST00000333175.9 [Q4ZIN3-2] ENST00000593068.7 ENST00000592590.6

TMEM259 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review