TMBIM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	17 studies	22% ± 7%	Explore
natural killer cell	15 studies	19% ± 3%	Explore
epithelial cell	14 studies	35% ± 14%	Explore
fibroblast	14 studies	25% ± 10%	Explore
endothelial cell	11 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	10 studies	24% ± 7%	Explore
basal cell	10 studies	29% ± 11%	Explore
platelet	8 studies	33% ± 11%	Explore
astrocyte	8 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	25% ± 6%	Explore
type I pneumocyte	7 studies	26% ± 8%	Explore
non-classical monocyte	7 studies	25% ± 8%	Explore
capillary endothelial cell	7 studies	26% ± 6%	Explore
memory B cell	7 studies	19% ± 3%	Explore
mucosal invariant T cell	7 studies	18% ± 3%	Explore
myofibroblast cell	7 studies	22% ± 9%	Explore
endothelial cell of vascular tree	7 studies	21% ± 5%	Explore
alveolar macrophage	6 studies	23% ± 4%	Explore
enterocyte	6 studies	24% ± 6%	Explore
pericyte	6 studies	18% ± 2%	Explore
ciliated cell	6 studies	25% ± 10%	Explore
endothelial cell of artery	6 studies	24% ± 7%	Explore
secretory cell	6 studies	28% ± 10%	Explore
gamma-delta T cell	6 studies	21% ± 5%	Explore
classical monocyte	5 studies	24% ± 7%	Explore
conventional dendritic cell	5 studies	22% ± 4%	Explore
mature NK T cell	5 studies	17% ± 2%	Explore
CD8-positive, alpha-beta T cell	5 studies	16% ± 1%	Explore
adipocyte	5 studies	28% ± 5%	Explore
squamous epithelial cell	4 studies	59% ± 15%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
megakaryocyte	4 studies	41% ± 17%	Explore
smooth muscle cell	4 studies	25% ± 3%	Explore
myeloid cell	4 studies	26% ± 4%	Explore
goblet cell	4 studies	21% ± 3%	Explore
oligodendrocyte	4 studies	19% ± 3%	Explore
abnormal cell	4 studies	27% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
regulatory T cell	4 studies	18% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
vein endothelial cell	4 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 2%	Explore
monocyte	3 studies	21% ± 4%	Explore
extravillous trophoblast	3 studies	23% ± 4%	Explore
naive B cell	3 studies	16% ± 1%	Explore
B cell	3 studies	16% ± 1%	Explore
dendritic cell	3 studies	27% ± 7%	Explore
pancreatic ductal cell	3 studies	63% ± 27%	Explore
connective tissue cell	3 studies	17% ± 2%	Explore
mast cell	3 studies	26% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	19% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	17% ± 2%	Explore
lung	9 studies	23% ± 6%	Explore
brain	4 studies	19% ± 4%	Explore
placenta	3 studies	22% ± 4%	Explore
esophagus	3 studies	33% ± 14%	Explore
intestine	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	19871.78	1445 / 1445	100%	196.54	183 / 183
intestine	100%	13702.27	966 / 966	100%	198.57	526 / 527
lung	100%	19464.48	578 / 578	100%	174.72	1152 / 1155
thymus	100%	16865.42	653 / 653	100%	206.00	603 / 605
kidney	100%	12115.39	89 / 89	100%	143.80	897 / 901
pancreas	100%	14619.04	328 / 328	99%	307.08	177 / 178
stomach	100%	17514.74	359 / 359	99%	179.21	284 / 286
liver	100%	9868.12	225 / 226	100%	111.29	404 / 406
skin	100%	16286.43	1809 / 1809	99%	137.20	466 / 472
ovary	100%	9604.77	180 / 180	99%	93.72	424 / 430
breast	100%	18233.28	459 / 459	98%	94.64	1100 / 1118
bladder	100%	17038.33	21 / 21	97%	186.47	491 / 504
prostate	100%	11201.91	245 / 245	97%	127.54	487 / 502
uterus	100%	13182.02	170 / 170	97%	139.31	445 / 459
adrenal gland	100%	12497.33	258 / 258	82%	59.16	188 / 230
brain	78%	5714.75	2049 / 2642	77%	66.50	542 / 705
adipose	100%	21930.75	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	129.55	80 / 80
muscle	100%	11950.44	803 / 803	0%	0	0 / 0
spleen	100%	7276.33	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	183.74	45 / 45
ureter	0%	0	0 / 0	100%	159.62	1 / 1
blood vessel	100%	22102.57	1334 / 1335	0%	0	0 / 0
heart	98%	8382.81	842 / 861	0%	0	0 / 0
peripheral blood	95%	7604.83	878 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	57.06	25 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1902042	Biological process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_2000504	Biological process	positive regulation of blood vessel remodeling
GO_1902045	Biological process	negative regulation of Fas signaling pathway
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0043086	Biological process	negative regulation of catalytic activity
GO_1903077	Biological process	negative regulation of protein localization to plasma membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0010008	Cellular component	endosome membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0016020	Cellular component	membrane
GO_0005123	Molecular function	death receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMBIM1
Protein name	Transmembrane BAX inhibitor motif containing 1 (cDNA FLJ36592 fis, clone TRACH2014046, highly similar to Transmembrane BAX inhibitor motif-containing protein 1) (cDNA FLJ54055, highly similar to Transmembrane BAX inhibitor motif-containing protein 1) Transmembrane BAX inhibitor motif containing 1 Transmembrane BAX inhibitor motif containing 1 (cDNA FLJ53658, highly similar to Transmembrane BAX inhibitor motif-containing protein 1) Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1)
Synonyms	LFG3 PSEC0158 RECS1 PP1201
Description	FUNCTION: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
Accessions	C9IZ27 C9JN47 ENST00000437694.6 ENST00000444000.5 ENST00000258412.8 ENST00000420341.1 ENST00000434015.2 Q969X1 ENST00000453281.5 B4DUD2 ENST00000413976.1 ENST00000425694.5 ENST00000440422.5 A0A1D5RMQ2 C9JEN3 C9IYT2 B3KSM0 C9JW19 C9JDV0 ENST00000418569.5 ENST00000445635.5 ENST00000396809.6 ENST00000429501.5 ENST00000444881.5 ENST00000451181.5 F8WDY4 ENST00000439306.5 C9JAP5 C9JI44 ENST00000453776.5 ENST00000444183.5 C9JM62 C9JAK9 C9JWV9

TMBIM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review