TDRD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTDRD3
Protein nameTudor domain-containing protein 3
Tudor domain containing 3
Synonyms
DescriptionFUNCTION: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins . Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci . In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 . .

AccessionsB1AMN9
ENST00000196169.7 [Q9H7E2-1]
F2Z2Y2
ENST00000621840.4 [Q9H7E2-2]
ENST00000377882.7
ENST00000377894.6 [Q9H7E2-1]
ENST00000377881.8 [Q9H7E2-3]
ENST00000648252.1 [Q9H7E2-1]
ENST00000484389.6
Q9H7E2