TAOK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901985Biological processpositive regulation of protein acetylation
GO_0006281Biological processDNA repair
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0051493Biological processregulation of cytoskeleton organization
GO_0046330Biological processpositive regulation of JNK cascade
GO_0006974Biological processDNA damage response
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0070050Biological processneuron cellular homeostasis
GO_0021954Biological processcentral nervous system neuron development
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0097194Biological processexecution phase of apoptosis
GO_0016310Biological processphosphorylation
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0048487Molecular functionbeta-tubulin binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0016740Molecular functiontransferase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0043014Molecular functionalpha-tubulin binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAOK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)
SynonymsMAP3K16
MARKK
KIAA1361
DescriptionFUNCTION: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system . Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). .

AccessionsA0A994J797
ENST00000583121.5
ENST00000536202.1 [Q7L7X3-3]
ENST00000578653.1
Q7L7X3
ENST00000261716.8 [Q7L7X3-1]
J3QS76