STXBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	30% ± 17%	Explore
glutamatergic neuron	12 studies	63% ± 27%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 11%	Explore
retinal rod cell	9 studies	37% ± 12%	Explore
astrocyte	9 studies	23% ± 10%	Explore
GABAergic neuron	8 studies	57% ± 22%	Explore
retinal cone cell	8 studies	46% ± 16%	Explore
neuron	7 studies	45% ± 15%	Explore
amacrine cell	6 studies	40% ± 10%	Explore
interneuron	6 studies	60% ± 23%	Explore
retinal ganglion cell	6 studies	72% ± 27%	Explore
type II pneumocyte	6 studies	26% ± 6%	Explore
retina horizontal cell	5 studies	31% ± 7%	Explore
fibroblast	5 studies	19% ± 2%	Explore
oligodendrocyte	5 studies	23% ± 10%	Explore
retinal bipolar neuron	4 studies	35% ± 9%	Explore
epithelial cell	4 studies	21% ± 5%	Explore
granule cell	4 studies	47% ± 13%	Explore
adipocyte	4 studies	23% ± 2%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 4%	Explore
type B pancreatic cell	3 studies	53% ± 30%	Explore
GABAergic interneuron	3 studies	52% ± 2%	Explore
OFF-bipolar cell	3 studies	58% ± 25%	Explore
ON-bipolar cell	3 studies	55% ± 28%	Explore
rod bipolar cell	3 studies	41% ± 5%	Explore
ciliated cell	3 studies	17% ± 1%	Explore
club cell	3 studies	21% ± 4%	Explore
goblet cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	45% ± 22%	Explore
eye	9 studies	34% ± 9%	Explore
pancreas	3 studies	41% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	31250.44	2607 / 2642	100%	67.30	702 / 705
ovary	100%	5515.39	180 / 180	97%	15.64	416 / 430
thymus	99%	4844.06	649 / 653	96%	19.25	582 / 605
adrenal gland	96%	3944.11	248 / 258	97%	77.45	224 / 230
lung	99%	5218.83	573 / 578	88%	19.07	1013 / 1155
breast	99%	4639.04	454 / 459	78%	10.06	877 / 1118
skin	77%	2226.97	1401 / 1809	100%	96.63	471 / 472
prostate	81%	2697.69	199 / 245	87%	10.88	435 / 502
uterus	99%	5859.30	168 / 170	67%	8.24	308 / 459
esophagus	70%	2398.25	1011 / 1445	87%	16.02	160 / 183
kidney	75%	2358.28	67 / 89	79%	14.20	711 / 901
intestine	70%	2597.54	679 / 966	83%	15.68	439 / 527
pancreas	46%	1167.27	152 / 328	92%	17.20	163 / 178
bladder	86%	3309.81	18 / 21	50%	7.47	251 / 504
stomach	42%	1894.20	152 / 359	78%	12.92	222 / 286
eye	0%	0	0 / 0	100%	49.02	80 / 80
adipose	100%	5533.13	1202 / 1204	0%	0	0 / 0
blood vessel	93%	3245.74	1235 / 1335	0%	0	0 / 0
heart	86%	2724.13	740 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	9.77	35 / 45
spleen	54%	1426.66	129 / 241	0%	0	0 / 0
liver	0%	9.35	1 / 226	19%	1.58	77 / 406
muscle	3%	64.04	23 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043306	Biological process	positive regulation of mast cell degranulation
GO_0016188	Biological process	synaptic vesicle maturation
GO_0032355	Biological process	response to estradiol
GO_0072659	Biological process	protein localization to plasma membrane
GO_0070527	Biological process	platelet aggregation
GO_0007269	Biological process	neurotransmitter secretion
GO_1903296	Biological process	positive regulation of glutamate secretion, neurotransmission
GO_0002576	Biological process	platelet degranulation
GO_0031333	Biological process	negative regulation of protein-containing complex assembly
GO_0031630	Biological process	regulation of synaptic vesicle fusion to presynaptic active zone membrane
GO_0006886	Biological process	intracellular protein transport
GO_0060292	Biological process	long-term synaptic depression
GO_0007274	Biological process	neuromuscular synaptic transmission
GO_0032229	Biological process	negative regulation of synaptic transmission, GABAergic
GO_0035493	Biological process	SNARE complex assembly
GO_2000367	Biological process	regulation of acrosomal vesicle exocytosis
GO_0051402	Biological process	neuron apoptotic process
GO_0016192	Biological process	vesicle-mediated transport
GO_0006904	Biological process	vesicle docking involved in exocytosis
GO_0099525	Biological process	presynaptic dense core vesicle exocytosis
GO_0010807	Biological process	regulation of synaptic vesicle priming
GO_0016082	Biological process	synaptic vesicle priming
GO_0050821	Biological process	protein stabilization
GO_0045956	Biological process	positive regulation of calcium ion-dependent exocytosis
GO_0007412	Biological process	axon target recognition
GO_0106022	Biological process	positive regulation of vesicle docking
GO_0035542	Biological process	regulation of SNARE complex assembly
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0003006	Biological process	developmental process involved in reproduction
GO_0071346	Biological process	cellular response to type II interferon
GO_0098978	Cellular component	glutamatergic synapse
GO_0031091	Cellular component	platelet alpha granule
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0098794	Cellular component	postsynapse
GO_0005829	Cellular component	cytosol
GO_0045335	Cellular component	phagocytic vesicle
GO_0005737	Cellular component	cytoplasm
GO_0098888	Cellular component	extrinsic component of presynaptic membrane
GO_0099523	Cellular component	presynaptic cytosol
GO_0030424	Cellular component	axon
GO_0030141	Cellular component	secretory granule
GO_0098688	Cellular component	parallel fiber to Purkinje cell synapse
GO_0098831	Cellular component	presynaptic active zone cytoplasmic component
GO_0019904	Molecular function	protein domain specific binding
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0017075	Molecular function	syntaxin-1 binding
GO_0000149	Molecular function	SNARE binding
GO_0043274	Molecular function	phospholipase binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0019905	Molecular function	syntaxin binding

IV. Literature review

[source]

Gene name	STXBP1
Protein name	Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Protein unc-18 homolog A) Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) Syntaxin binding protein 1
Synonyms	UNC18A
Description	FUNCTION: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. .
Accessions	A0A096LP52 ENST00000496504.3 ENST00000373299.5 [P61764-1] ENST00000704681.1 A0A1B0GTD8 ENST00000637464.2 ENST00000637060.2 ENST00000476182.3 ENST00000704680.1 ENST00000637521.2 ENST00000630492.2 ENST00000494254.3 A0A0D9SEP9 ENST00000625363.2 A0A1B0GUQ2 ENST00000627871.2 ENST00000635950.2 ENST00000647107.1 A0A1B0GVQ5 A0A994J7L2 A0A0D9SEH5 A0A1B0GWF2 ENST00000626333.1 ENST00000636962.2 ENST00000636509.2 ENST00000637953.1 A0A0D9SG72 ENST00000637173.2 ENST00000650920.1 A0A1B0GVV9 A0A0D9SFW6 A0A2R8Y5D4 P61764 A0A096LP33 A0A1B0GTP9 A0A0D9SFQ7 ENST00000626539.3 A0A1B0GW76 ENST00000373302.8 [P61764-2]

STXBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review