SPOP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030162Biological processregulation of proteolysis
GO_0000209Biological processprotein polyubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameSPOP
Protein nameSpeckle type BTB/POZ protein
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Synonyms
DescriptionFUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability . Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation . Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 . Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication . Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A . In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II . .

AccessionsENST00000505581.5
ENST00000510476.5
ENST00000504212.5
ENST00000659760.1
A0A590UJA7
ENST00000503676.5
ENST00000347630.6
D6RA79
ENST00000665825.1
D6RDG8
ENST00000504102.6
ENST00000513080.6
D6RD94
O43791
ENST00000671445.1
ENST00000514121.6
H0Y977
D6RIS7
ENST00000509869.5
D6RFL7
D6RGZ4
ENST00000393328.6
ENST00000508805.5
D6RBR3
ENST00000451526.6
ENST00000506399.5
ENST00000515508.6
ENST00000509079.6
ENST00000507970.5