SPG21 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	28 studies	27% ± 10%	Explore
classical monocyte	21 studies	31% ± 10%	Explore
conventional dendritic cell	19 studies	29% ± 13%	Explore
monocyte	18 studies	29% ± 11%	Explore
non-classical monocyte	17 studies	28% ± 12%	Explore
fibroblast	13 studies	24% ± 8%	Explore
B cell	12 studies	21% ± 5%	Explore
naive B cell	12 studies	18% ± 2%	Explore
endothelial cell	9 studies	27% ± 11%	Explore
dendritic cell	9 studies	31% ± 18%	Explore
memory B cell	8 studies	18% ± 2%	Explore
myeloid cell	8 studies	30% ± 10%	Explore
ciliated cell	8 studies	26% ± 8%	Explore
connective tissue cell	7 studies	22% ± 5%	Explore
epithelial cell	7 studies	38% ± 18%	Explore
alveolar macrophage	7 studies	28% ± 10%	Explore
plasmacytoid dendritic cell	7 studies	24% ± 10%	Explore
pericyte	6 studies	22% ± 6%	Explore
smooth muscle cell	6 studies	18% ± 2%	Explore
type II pneumocyte	6 studies	27% ± 16%	Explore
abnormal cell	6 studies	21% ± 6%	Explore
endothelial cell of lymphatic vessel	5 studies	22% ± 6%	Explore
astrocyte	5 studies	20% ± 5%	Explore
basal cell	5 studies	32% ± 11%	Explore
natural killer cell	5 studies	21% ± 7%	Explore
hematopoietic precursor cell	4 studies	25% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 2%	Explore
CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
endothelial cell of vascular tree	4 studies	23% ± 5%	Explore
regulatory T cell	4 studies	21% ± 6%	Explore
mononuclear phagocyte	4 studies	31% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 1%	Explore
pancreatic A cell	3 studies	33% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	19% ± 2%	Explore
myofibroblast cell	3 studies	18% ± 1%	Explore
CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
common myeloid progenitor	3 studies	30% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	24% ± 6%	Explore
intermediate monocyte	3 studies	39% ± 21%	Explore
GABAergic neuron	3 studies	25% ± 8%	Explore
glutamatergic neuron	3 studies	31% ± 9%	Explore
enterocyte	3 studies	17% ± 1%	Explore
enteroendocrine cell	3 studies	25% ± 11%	Explore
goblet cell	3 studies	21% ± 6%	Explore
intestinal crypt stem cell	3 studies	21% ± 3%	Explore
hepatocyte	3 studies	30% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	23% ± 5%	Explore
lung	8 studies	25% ± 8%	Explore
brain	5 studies	23% ± 4%	Explore
pancreas	3 studies	35% ± 8%	Explore
intestine	3 studies	24% ± 11%	Explore
liver	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4840.19	21 / 21	100%	85.58	504 / 504
breast	100%	4297.83	459 / 459	100%	92.94	1118 / 1118
esophagus	100%	3889.14	1445 / 1445	100%	63.78	183 / 183
kidney	100%	4295.99	89 / 89	100%	67.52	901 / 901
liver	100%	3460.33	226 / 226	100%	66.89	406 / 406
lung	100%	4440.89	578 / 578	100%	86.89	1155 / 1155
ovary	100%	4210.05	180 / 180	100%	95.00	430 / 430
prostate	100%	4201.55	245 / 245	100%	96.34	502 / 502
skin	100%	5078.12	1809 / 1809	100%	106.84	472 / 472
stomach	100%	3812.19	359 / 359	100%	68.70	286 / 286
uterus	100%	4493.22	170 / 170	100%	86.62	459 / 459
thymus	100%	5028.99	653 / 653	100%	90.68	604 / 605
intestine	100%	4333.39	966 / 966	100%	77.03	526 / 527
brain	100%	2450.11	2635 / 2642	100%	67.58	705 / 705
pancreas	100%	2112.20	327 / 328	100%	72.63	178 / 178
adrenal gland	100%	4735.90	258 / 258	99%	52.61	227 / 230
adipose	100%	4477.57	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	92.63	80 / 80
lymph node	0%	0	0 / 0	100%	81.21	29 / 29
muscle	100%	3305.01	803 / 803	0%	0	0 / 0
spleen	100%	4174.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.19	45 / 45
ureter	0%	0	0 / 0	100%	52.21	1 / 1
blood vessel	100%	3721.94	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	5291.03	923 / 929	0%	0	0 / 0
heart	97%	2430.07	836 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050851	Biological process	antigen receptor-mediated signaling pathway
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0010008	Cellular component	endosome membrane
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0030140	Cellular component	trans-Golgi network transport vesicle
GO_0005515	Molecular function	protein binding
GO_0042609	Molecular function	CD4 receptor binding

IV. Literature review

[source]

Gene name	SPG21
Protein name	Maspardin Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) SPG21 abhydrolase domain containing, maspardin
Synonyms	BM-019 GL010 ACP33
Description	FUNCTION: May play a role as a negative regulatory factor in CD4-dependent T-cell activation. . FUNCTION: May play a role as a negative regulatory factor in CD4-dependent T-cell activation. . FUNCTION: May play a role as a negative regulatory factor in CD4-dependent T-cell activation. .
Accessions	H0YLT5 ENST00000557795.5 H0YML6 H3BRR0 ENST00000559677.5 H0YKB0 ENST00000433215.6 [Q9NZD8-1] H0YMB7 ENST00000560878.1 ENST00000416889.6 [Q9NZD8-2] Q9NZD8 H0YKM6 H0YLD7 ENST00000558765.5 ENST00000561078.5 ENST00000204566.7 [Q9NZD8-1] ENST00000558415.5 H0YLW1 ENST00000558943.5 ENST00000559199.5

SPG21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review