SP140 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SP140 at tissue level.

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006952Biological processdefense response
GO_0001650Cellular componentfibrillar center
GO_0016605Cellular componentPML body
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameSP140
Protein nameNuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa)
SP140 protein
SP140 nuclear body protein
SynonymsLYSP100
DescriptionFUNCTION: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body . May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection . May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails . .

AccessionsENST00000343805.10 [Q13342-6]
ENST00000417495.7 [Q13342-3]
ENST00000456542.5
U3KPV9
ENST00000420434.7 [Q13342-5]
ENST00000392045.8 [Q13342-1]
ENST00000373645.3 [Q13342-4]
Q13342
Q0VGE4
Q7Z2U4