SNX9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0006897Biological processendocytosis
GO_0051044Biological processpositive regulation of membrane protein ectodomain proteolysis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0006898Biological processreceptor-mediated endocytosis
GO_1900242Biological processregulation of synaptic vesicle endocytosis
GO_0006886Biological processintracellular protein transport
GO_0000281Biological processmitotic cytokinesis
GO_0097320Biological processplasma membrane tubulation
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0065003Biological processprotein-containing complex assembly
GO_0016197Biological processendosomal transport
GO_0036089Biological processcleavage furrow formation
GO_0060988Biological processlipid tube assembly
GO_0001726Cellular componentruffle
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005802Cellular componenttrans-Golgi network
GO_0032437Cellular componentcuticular plate
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005905Cellular componentclathrin-coated pit
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0071933Molecular functionArp2/3 complex binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNX9
Protein nameSorting nexin
Sorting nexin 9
Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)
SynonymsSH3PXD3A
SH3PX1
DescriptionFUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. .

AccessionsENST00000679814.1
A0A7P0T8L2
ENST00000681186.1
A0A087WZW2
ENST00000679790.1
A0A7P0T8C7
Q9Y5X1
ENST00000614800.4
A0A7P0Z4A5
A0A7P0T8M2
A0A7P0T8Z7
ENST00000680863.1
A0A7P0TBD0
A0A7P0T8S8
ENST00000680495.1
A0A7P0Z4A2
A0A7P0T8Z2
ENST00000680078.1
ENST00000679732.1
ENST00000679691.1
ENST00000392185.8
ENST00000681534.1
ENST00000681183.1
A0A087WVE4
ENST00000681651.1
A0A7P0TBI9
A0A7P0T8D4
ENST00000681138.1
ENST00000614703.4