Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 25% ± 10% | |
| macrophage | 15 studies | 27% ± 10% | |
| fibroblast | 14 studies | 21% ± 5% | |
| oligodendrocyte precursor cell | 12 studies | 39% ± 17% | |
| oligodendrocyte | 12 studies | 41% ± 16% | |
| type I pneumocyte | 10 studies | 26% ± 7% | |
| microglial cell | 9 studies | 29% ± 12% | |
| B cell | 9 studies | 21% ± 6% | |
| classical monocyte | 8 studies | 22% ± 6% | |
| non-classical monocyte | 8 studies | 22% ± 6% | |
| myeloid cell | 8 studies | 26% ± 8% | |
| epithelial cell | 8 studies | 32% ± 16% | |
| astrocyte | 8 studies | 26% ± 10% | |
| natural killer cell | 7 studies | 18% ± 2% | |
| GABAergic neuron | 7 studies | 31% ± 17% | |
| pericyte | 7 studies | 18% ± 3% | |
| endothelial cell of lymphatic vessel | 7 studies | 20% ± 4% | |
| adipocyte | 7 studies | 21% ± 5% | |
| smooth muscle cell | 7 studies | 19% ± 2% | |
| CD8-positive, alpha-beta T cell | 6 studies | 17% ± 2% | |
| dendritic cell | 6 studies | 25% ± 12% | |
| naive B cell | 6 studies | 20% ± 4% | |
| type II pneumocyte | 6 studies | 23% ± 8% | |
| monocyte | 6 studies | 21% ± 5% | |
| plasmacytoid dendritic cell | 6 studies | 23% ± 6% | |
| conventional dendritic cell | 5 studies | 25% ± 10% | |
| ciliated cell | 5 studies | 24% ± 6% | |
| basal cell | 5 studies | 29% ± 9% | |
| interneuron | 5 studies | 30% ± 21% | |
| cardiac muscle cell | 4 studies | 29% ± 2% | |
| lymphocyte | 4 studies | 21% ± 3% | |
| regulatory T cell | 4 studies | 19% ± 2% | |
| glutamatergic neuron | 4 studies | 52% ± 19% | |
| goblet cell | 4 studies | 25% ± 11% | |
| gamma-delta T cell | 4 studies | 21% ± 9% | |
| progenitor cell | 3 studies | 18% ± 2% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 3% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 1% | |
| endothelial cell of vascular tree | 3 studies | 23% ± 4% | |
| myofibroblast cell | 3 studies | 22% ± 5% | |
| hepatocyte | 3 studies | 43% ± 23% | |
| muscle cell | 3 studies | 37% ± 14% | |
| abnormal cell | 3 studies | 28% ± 10% | |
| alveolar macrophage | 3 studies | 33% ± 11% | |
| transit amplifying cell | 3 studies | 28% ± 14% | |
| T cell | 3 studies | 17% ± 1% | |
| neuron | 3 studies | 34% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 9347.51 | 1445 / 1445 | 100% | 28.82 | 183 / 183 |
| lung | 100% | 11044.01 | 578 / 578 | 100% | 36.30 | 1155 / 1155 |
| ovary | 100% | 9220.17 | 180 / 180 | 100% | 25.49 | 430 / 430 |
| stomach | 100% | 7268.39 | 359 / 359 | 100% | 25.72 | 286 / 286 |
| prostate | 100% | 10598.36 | 245 / 245 | 100% | 59.17 | 501 / 502 |
| brain | 100% | 5831.48 | 2636 / 2642 | 100% | 55.86 | 705 / 705 |
| thymus | 100% | 24565.45 | 653 / 653 | 100% | 160.34 | 603 / 605 |
| kidney | 100% | 7526.30 | 89 / 89 | 100% | 38.31 | 898 / 901 |
| skin | 100% | 8957.94 | 1809 / 1809 | 100% | 66.48 | 470 / 472 |
| intestine | 100% | 9205.82 | 966 / 966 | 99% | 27.06 | 524 / 527 |
| bladder | 100% | 9243.33 | 21 / 21 | 99% | 32.68 | 501 / 504 |
| breast | 100% | 10099.51 | 459 / 459 | 99% | 51.12 | 1111 / 1118 |
| uterus | 100% | 11504.56 | 170 / 170 | 99% | 38.42 | 455 / 459 |
| adrenal gland | 100% | 10366.21 | 258 / 258 | 99% | 34.74 | 227 / 230 |
| pancreas | 100% | 4483.98 | 327 / 328 | 99% | 35.31 | 176 / 178 |
| liver | 100% | 5272.84 | 226 / 226 | 98% | 24.59 | 396 / 406 |
| adipose | 100% | 10294.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 8999.93 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 37.43 | 29 / 29 |
| spleen | 100% | 9802.15 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 36.66 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 16.73 | 1 / 1 |
| muscle | 100% | 5246.75 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 5577.19 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 96% | 6640.65 | 896 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 33.89 | 76 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031623 | Biological process | receptor internalization |
| GO_0072673 | Biological process | lamellipodium morphogenesis |
| GO_0034498 | Biological process | early endosome to Golgi transport |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
| GO_0016020 | Cellular component | membrane |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0030904 | Cellular component | retromer complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0030905 | Cellular component | retromer, tubulation complex |
| GO_0005768 | Cellular component | endosome |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0031982 | Cellular component | vesicle |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005158 | Molecular function | insulin receptor binding |
| GO_1990459 | Molecular function | transferrin receptor binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0005154 | Molecular function | epidermal growth factor receptor binding |
| GO_1990460 | Molecular function | leptin receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SNX1 |
| Protein name | Sorting nexin-1 Sorting nexin 1 |
| Synonyms | |
| Description | FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi . Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R . Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN . Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking . . |
| Accessions | H0YK43 ENST00000560861.1 ENST00000561026.5 [Q13596-2] ENST00000560260.5 ENST00000558040.5 ENST00000559061.5 H0YKL5 ENST00000560829.5 H0YK42 H0YK58 J3KPH4 Q13596 ENST00000380285.7 ENST00000625244.2 H0YKT3 ENST00000261889.9 [Q13596-3] H0YKD5 ENST00000559844.6 [Q13596-1] ENST00000559389.1 |