SNX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031623Biological processreceptor internalization
GO_0072673Biological processlamellipodium morphogenesis
GO_0034498Biological processearly endosome to Golgi transport
GO_0006886Biological processintracellular protein transport
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0030905Cellular componentretromer, tubulation complex
GO_0005768Cellular componentendosome
GO_0030027Cellular componentlamellipodium
GO_0031982Cellular componentvesicle
GO_0042803Molecular functionprotein homodimerization activity
GO_0005158Molecular functioninsulin receptor binding
GO_1990459Molecular functiontransferrin receptor binding
GO_0045296Molecular functioncadherin binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_1990460Molecular functionleptin receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNX1
Protein nameSorting nexin-1
Sorting nexin 1
Synonyms
DescriptionFUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi . Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R . Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN . Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking . .

AccessionsH0YK43
ENST00000560861.1
ENST00000561026.5 [Q13596-2]
ENST00000560260.5
ENST00000558040.5
ENST00000559061.5
H0YKL5
ENST00000560829.5
H0YK42
H0YK58
J3KPH4
Q13596
ENST00000380285.7
ENST00000625244.2
H0YKT3
ENST00000261889.9 [Q13596-3]
H0YKD5
ENST00000559844.6 [Q13596-1]
ENST00000559389.1