SMS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	32% ± 10%	Explore
classical monocyte	18 studies	25% ± 10%	Explore
conventional dendritic cell	18 studies	25% ± 11%	Explore
regulatory T cell	18 studies	24% ± 6%	Explore
non-classical monocyte	16 studies	26% ± 11%	Explore
fibroblast	16 studies	28% ± 10%	Explore
endothelial cell	15 studies	31% ± 14%	Explore
epithelial cell	15 studies	38% ± 22%	Explore
natural killer cell	14 studies	25% ± 8%	Explore
monocyte	13 studies	20% ± 5%	Explore
basal cell	12 studies	35% ± 16%	Explore
myeloid cell	11 studies	31% ± 12%	Explore
B cell	10 studies	25% ± 11%	Explore
microglial cell	10 studies	23% ± 8%	Explore
astrocyte	10 studies	32% ± 13%	Explore
dendritic cell	10 studies	30% ± 18%	Explore
ciliated cell	9 studies	34% ± 17%	Explore
CD8-positive, alpha-beta T cell	9 studies	26% ± 9%	Explore
abnormal cell	9 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 4%	Explore
connective tissue cell	8 studies	28% ± 8%	Explore
T cell	8 studies	25% ± 10%	Explore
smooth muscle cell	8 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	8 studies	20% ± 5%	Explore
myofibroblast cell	7 studies	20% ± 3%	Explore
neuron	7 studies	38% ± 17%	Explore
goblet cell	7 studies	24% ± 13%	Explore
memory B cell	7 studies	17% ± 1%	Explore
alveolar macrophage	6 studies	24% ± 3%	Explore
secretory cell	6 studies	29% ± 16%	Explore
mononuclear phagocyte	6 studies	27% ± 13%	Explore
CD4-positive, alpha-beta T cell	6 studies	35% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	39% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	41% ± 13%	Explore
leukocyte	6 studies	28% ± 7%	Explore
pericyte	6 studies	22% ± 6%	Explore
transit amplifying cell	6 studies	25% ± 7%	Explore
hematopoietic precursor cell	5 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
progenitor cell	5 studies	31% ± 7%	Explore
enterocyte	5 studies	18% ± 2%	Explore
mesothelial cell	5 studies	35% ± 11%	Explore
glutamatergic neuron	5 studies	47% ± 22%	Explore
erythroblast	5 studies	33% ± 14%	Explore
pro-B cell	5 studies	29% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	25% ± 7%	Explore
club cell	4 studies	23% ± 5%	Explore
ionocyte	4 studies	35% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	58% ± 12%	Explore
enteroendocrine cell	4 studies	35% ± 14%	Explore
intestinal crypt stem cell	4 studies	26% ± 7%	Explore
retinal ganglion cell	4 studies	59% ± 29%	Explore
hematopoietic stem cell	4 studies	23% ± 5%	Explore
innate lymphoid cell	4 studies	20% ± 4%	Explore
retina horizontal cell	4 studies	26% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 3%	Explore
luminal cell of prostate epithelium	4 studies	36% ± 13%	Explore
GABAergic neuron	4 studies	42% ± 14%	Explore
interneuron	4 studies	33% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 8%	Explore
duct epithelial cell	3 studies	24% ± 3%	Explore
pancreatic A cell	3 studies	39% ± 8%	Explore
type B pancreatic cell	3 studies	36% ± 7%	Explore
renal alpha-intercalated cell	3 studies	30% ± 3%	Explore
endothelial cell of artery	3 studies	46% ± 19%	Explore
neural crest cell	3 studies	28% ± 6%	Explore
extravillous trophoblast	3 studies	67% ± 7%	Explore
placental villous trophoblast	3 studies	92% ± 3%	Explore
common myeloid progenitor	3 studies	27% ± 14%	Explore
amacrine cell	3 studies	33% ± 11%	Explore
serous secreting cell	3 studies	22% ± 4%	Explore
tissue-resident macrophage	3 studies	25% ± 11%	Explore
germinal center B cell	3 studies	30% ± 5%	Explore
precursor B cell	3 studies	29% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
intermediate monocyte	3 studies	35% ± 9%	Explore
type I pneumocyte	3 studies	24% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
pancreatic ductal cell	3 studies	56% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	43% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 10%	Explore
double negative thymocyte	3 studies	28% ± 17%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	12 studies	29% ± 14%	Explore
peripheral blood	9 studies	21% ± 5%	Explore
kidney	8 studies	25% ± 5%	Explore
brain	7 studies	32% ± 15%	Explore
intestine	6 studies	24% ± 10%	Explore
eye	6 studies	23% ± 9%	Explore
lymph node	4 studies	26% ± 12%	Explore
breast	4 studies	20% ± 4%	Explore
pancreas	3 studies	41% ± 5%	Explore
placenta	3 studies	68% ± 12%	Explore
adrenal gland	3 studies	25% ± 10%	Explore
prostate	3 studies	26% ± 7%	Explore
liver	3 studies	35% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3470.97	966 / 966	100%	166.84	527 / 527
prostate	100%	5541.20	245 / 245	100%	811.42	502 / 502
breast	100%	2640.32	459 / 459	100%	220.96	1116 / 1118
uterus	100%	3124.59	170 / 170	100%	211.91	458 / 459
ovary	100%	5886.56	180 / 180	100%	142.94	429 / 430
kidney	100%	5287.19	89 / 89	100%	152.54	897 / 901
lung	100%	2982.20	576 / 578	100%	172.26	1153 / 1155
stomach	100%	2436.29	359 / 359	99%	156.64	284 / 286
adrenal gland	100%	7341.31	258 / 258	99%	205.44	228 / 230
thymus	100%	4246.47	653 / 653	99%	117.14	599 / 605
esophagus	100%	2730.63	1445 / 1445	99%	138.62	181 / 183
bladder	100%	3401.10	21 / 21	99%	174.22	498 / 504
skin	99%	3632.98	1799 / 1809	99%	202.90	467 / 472
brain	99%	3480.31	2627 / 2642	97%	111.17	683 / 705
pancreas	94%	1074.46	309 / 328	99%	136.15	176 / 178
liver	97%	1171.54	220 / 226	83%	61.61	338 / 406
lymph node	0%	0	0 / 0	100%	172.37	29 / 29
spleen	100%	2258.75	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	147.74	45 / 45
ureter	0%	0	0 / 0	100%	50.96	1 / 1
blood vessel	100%	3297.16	1334 / 1335	0%	0	0 / 0
adipose	100%	2276.32	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	154.68	79 / 80
muscle	98%	1515.57	786 / 803	0%	0	0 / 0
heart	95%	2414.04	816 / 861	0%	0	0 / 0
peripheral blood	81%	2416.06	749 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006597	Biological process	spermine biosynthetic process
GO_0006555	Biological process	methionine metabolic process
GO_0006595	Biological process	polyamine metabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0016768	Molecular function	spermine synthase activity

Gene name	SMS
Protein name	Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) Spermine synthase
Synonyms
Description	FUNCTION: Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). .
Accessions	ENST00000404933.7 [P52788-1] H7C2R7 ENST00000379404.5 [P52788-2] ENST00000457085.2 P52788

SMS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review