SMC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905821Biological processpositive regulation of chromosome condensation
GO_0045132Biological processmeiotic chromosome segregation
GO_0010032Biological processmeiotic chromosome condensation
GO_0000070Biological processmitotic sister chromatid segregation
GO_0051301Biological processcell division
GO_0051984Biological processpositive regulation of chromosome segregation
GO_1905820Biological processpositive regulation of chromosome separation
GO_0007076Biological processmitotic chromosome condensation
GO_0051383Biological processkinetochore organization
GO_0000775Cellular componentchromosome, centromeric region
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000796Cellular componentcondensin complex
GO_0005829Cellular componentcytosol
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMC4
Protein nameStructural maintenance of chromosomes protein
SMC4 protein
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)
Structural maintenance of chromosomes 4
SynonymsCAPC
SMC4L1
DescriptionFUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. .

AccessionsQ9NTJ3
C9JWF0
Q58F29
ENST00000465903.5
ENST00000490207.5
Q6P169
ENST00000485867.5
C9J9E4
C9JR83
ENST00000344722.5 [Q9NTJ3-1]
F8WCB7
C9JVD8
ENST00000467468.5
ENST00000357388.8 [Q9NTJ3-1]
ENST00000462787.5 [Q9NTJ3-2]
ENST00000469762.5
ENST00000489573.5
C9J578
Q6NSG3
ENST00000469858.5
ENST00000472991.5
E9PD53
ENST00000485645.5
C9JJ64
C9IYK2
ENST00000497311.5