SLU7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	20% ± 6%	Explore
B cell	11 studies	21% ± 8%	Explore
regulatory T cell	10 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 8%	Explore
plasmacytoid dendritic cell	9 studies	21% ± 6%	Explore
naive B cell	8 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 4%	Explore
endothelial cell	7 studies	25% ± 6%	Explore
gamma-delta T cell	7 studies	23% ± 11%	Explore
memory B cell	6 studies	17% ± 2%	Explore
classical monocyte	5 studies	26% ± 11%	Explore
non-classical monocyte	5 studies	33% ± 14%	Explore
mature NK T cell	5 studies	18% ± 3%	Explore
fibroblast	5 studies	23% ± 7%	Explore
epithelial cell	5 studies	38% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	4 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 9%	Explore
ciliated cell	4 studies	26% ± 9%	Explore
T cell	3 studies	27% ± 8%	Explore
type B pancreatic cell	3 studies	30% ± 12%	Explore
leukocyte	3 studies	20% ± 2%	Explore
conventional dendritic cell	3 studies	36% ± 16%	Explore
neuron	3 studies	25% ± 7%	Explore
retinal bipolar neuron	3 studies	26% ± 8%	Explore
precursor B cell	3 studies	28% ± 7%	Explore
retina horizontal cell	3 studies	24% ± 9%	Explore
GABAergic neuron	3 studies	32% ± 5%	Explore
glutamatergic neuron	3 studies	44% ± 4%	Explore
goblet cell	3 studies	18% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	26% ± 10%	Explore
lung	4 studies	19% ± 3%	Explore
brain	4 studies	27% ± 8%	Explore
eye	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3270.84	2642 / 2642	100%	50.36	705 / 705
esophagus	100%	2481.87	1445 / 1445	100%	29.34	183 / 183
lung	100%	2466.54	578 / 578	100%	32.21	1155 / 1155
ovary	100%	2331.05	180 / 180	100%	28.44	430 / 430
prostate	100%	2231.04	245 / 245	100%	37.09	502 / 502
thymus	100%	2842.58	653 / 653	100%	53.27	605 / 605
uterus	100%	2493.02	170 / 170	100%	33.85	459 / 459
breast	100%	2945.00	459 / 459	100%	45.65	1117 / 1118
bladder	100%	2482.48	21 / 21	99%	29.08	501 / 504
kidney	100%	1887.99	89 / 89	99%	36.01	894 / 901
intestine	100%	2610.34	966 / 966	99%	31.12	522 / 527
stomach	100%	2070.42	359 / 359	99%	29.25	282 / 286
pancreas	98%	1310.23	323 / 328	100%	32.60	178 / 178
liver	99%	990.00	223 / 226	100%	21.79	405 / 406
adrenal gland	100%	2597.09	258 / 258	98%	36.44	225 / 230
skin	100%	2820.26	1809 / 1809	96%	39.13	452 / 472
adipose	100%	2833.48	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3173.76	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	41.17	29 / 29
muscle	100%	3476.80	803 / 803	0%	0	0 / 0
spleen	100%	2906.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.00	45 / 45
heart	97%	1838.71	839 / 861	0%	0	0 / 0
peripheral blood	97%	2457.37	903 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	89%	19.09	71 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034605	Biological process	cellular response to heat
GO_0006886	Biological process	intracellular protein transport
GO_0000389	Biological process	mRNA 3'-splice site recognition
GO_0000380	Biological process	alternative mRNA splicing, via spliceosome
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0030532	Cellular component	small nuclear ribonucleoprotein complex
GO_0005634	Cellular component	nucleus
GO_0030628	Molecular function	pre-mRNA 3'-splice site binding
GO_0000386	Molecular function	second spliceosomal transesterification activity
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SLU7
Protein name	Pre-mRNA-splicing factor SLU7 (hSlu7) Pre-mRNA-splicing factor SLU7
Synonyms
Description	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome . Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. . FUNCTION: Involved in pre-mRNA splicing. . FUNCTION: Involved in pre-mRNA splicing. . FUNCTION: Involved in pre-mRNA splicing. .
Accessions	ENST00000521826.5 ENST00000520664.1 ENST00000519349.5 E5RK41 A0A0C4DGD2 E5RGM7 ENST00000297151.9 O95391

SLU7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review