SLC4A7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0090383Biological processphagosome acidification
GO_0071363Biological processcellular response to growth factor stimulus
GO_0060117Biological processauditory receptor cell development
GO_0015698Biological processinorganic anion transport
GO_0006164Biological processpurine nucleotide biosynthetic process
GO_0051453Biological processregulation of intracellular pH
GO_0015701Biological processbicarbonate transport
GO_0006221Biological processpyrimidine nucleotide biosynthetic process
GO_0035725Biological processsodium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0032420Cellular componentstereocilium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008509Molecular functionmonoatomic anion transmembrane transporter activity
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0005515Molecular functionprotein binding
GO_0008510Molecular functionsodium:bicarbonate symporter activity

IV. Literature review

[source]
Gene nameSLC4A7
Protein nameSodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)
Anion exchange protein
SynonymsNBCn1
NBC2
BT
NBC3
SLC4A6
NBC2B
SBC2
DescriptionFUNCTION: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry . Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis . Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells . .; FUNCTION: [Isoform 6]: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. .

AccessionsENST00000455077.5 [Q9Y6M7-6]
H7C3C4
ENST00000428179.1
ENST00000425128.6
Q9Y6M7
ENST00000446700.5 [Q9Y6M7-12]
ENST00000437179.5 [Q9Y6M7-9]
ENST00000419036.5
ENST00000440156.5 [Q9Y6M7-8]
E9PFN4
ENST00000454389.6 [Q9Y6M7-7]
ENST00000428386.5 [Q9Y6M7-2]
C9JRP1
ENST00000445684.5
ENST00000457377.5 [Q9Y6M7-11]
ENST00000295736.9 [Q9Y6M7-1]
ENST00000437266.5 [Q9Y6M7-11]
A0A0A0MST8
ENST00000438530.5 [Q9Y6M7-10]
B5M450