Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 13 studies | 44% ± 18% | |
| type I pneumocyte | 10 studies | 35% ± 12% | |
| endothelial cell | 10 studies | 31% ± 10% | |
| GABAergic neuron | 8 studies | 33% ± 17% | |
| glutamatergic neuron | 7 studies | 37% ± 22% | |
| hepatocyte | 4 studies | 53% ± 27% | |
| ciliated cell | 4 studies | 36% ± 12% | |
| interneuron | 4 studies | 44% ± 24% | |
| GABAergic amacrine cell | 3 studies | 25% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 33% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1671.41 | 2633 / 2642 | 91% | 35.76 | 640 / 705 |
| kidney | 100% | 2008.92 | 89 / 89 | 89% | 55.95 | 801 / 901 |
| prostate | 92% | 888.82 | 226 / 245 | 84% | 17.82 | 424 / 502 |
| thymus | 100% | 3301.53 | 652 / 653 | 75% | 23.99 | 451 / 605 |
| liver | 100% | 3589.53 | 226 / 226 | 74% | 29.90 | 300 / 406 |
| intestine | 95% | 1815.15 | 921 / 966 | 73% | 15.80 | 387 / 527 |
| breast | 96% | 765.28 | 442 / 459 | 62% | 48.54 | 691 / 1118 |
| lung | 99% | 1972.96 | 574 / 578 | 57% | 11.86 | 658 / 1155 |
| stomach | 75% | 651.15 | 268 / 359 | 73% | 15.03 | 209 / 286 |
| bladder | 100% | 788.33 | 21 / 21 | 43% | 6.53 | 219 / 504 |
| pancreas | 40% | 156.08 | 130 / 328 | 85% | 34.70 | 151 / 178 |
| uterus | 75% | 335.03 | 128 / 170 | 36% | 4.83 | 164 / 459 |
| esophagus | 50% | 206.39 | 719 / 1445 | 51% | 10.96 | 94 / 183 |
| adipose | 96% | 739.15 | 1150 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 24% | 96.62 | 63 / 258 | 60% | 13.41 | 138 / 230 |
| blood vessel | 73% | 299.94 | 981 / 1335 | 0% | 0 | 0 / 0 |
| skin | 40% | 444.93 | 726 / 1809 | 23% | 3.90 | 110 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 8.51 | 23 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 9.02 | 14 / 29 |
| heart | 34% | 126.17 | 297 / 861 | 0% | 0 | 0 / 0 |
| ovary | 11% | 31.62 | 19 / 180 | 15% | 1.41 | 65 / 430 |
| peripheral blood | 19% | 599.45 | 172 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 13% | 1.45 | 10 / 80 |
| muscle | 12% | 39.50 | 96 / 803 | 0% | 0 | 0 / 0 |
| spleen | 0% | 6.68 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070779 | Biological process | D-aspartate import across plasma membrane |
| GO_0071577 | Biological process | zinc ion transmembrane transport |
| GO_0070777 | Biological process | D-aspartate transmembrane transport |
| GO_0098877 | Biological process | neurotransmitter receptor transport to plasma membrane |
| GO_0070633 | Biological process | transepithelial transport |
| GO_0051938 | Biological process | L-glutamate import |
| GO_0071242 | Biological process | cellular response to ammonium ion |
| GO_0030534 | Biological process | adult behavior |
| GO_0001662 | Biological process | behavioral fear response |
| GO_0007613 | Biological process | memory |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0043278 | Biological process | response to morphine |
| GO_1990708 | Biological process | conditioned place preference |
| GO_0061744 | Biological process | motor behavior |
| GO_0090461 | Biological process | intracellular glutamate homeostasis |
| GO_0015813 | Biological process | L-glutamate transmembrane transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0098712 | Biological process | L-glutamate import across plasma membrane |
| GO_0042417 | Biological process | dopamine metabolic process |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_0006836 | Biological process | neurotransmitter transport |
| GO_0010467 | Biological process | gene expression |
| GO_0140009 | Biological process | L-aspartate import across plasma membrane |
| GO_0010460 | Biological process | positive regulation of heart rate |
| GO_0010842 | Biological process | retina layer formation |
| GO_1903926 | Biological process | cellular response to bisphenol A |
| GO_0022008 | Biological process | neurogenesis |
| GO_0034599 | Biological process | cellular response to oxidative stress |
| GO_0071314 | Biological process | cellular response to cocaine |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0006882 | Biological process | intracellular zinc ion homeostasis |
| GO_0007420 | Biological process | brain development |
| GO_0001975 | Biological process | response to amphetamine |
| GO_0006801 | Biological process | superoxide metabolic process |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0050808 | Biological process | synapse organization |
| GO_0070778 | Biological process | L-aspartate transmembrane transport |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0036293 | Biological process | response to decreased oxygen levels |
| GO_0007625 | Biological process | grooming behavior |
| GO_0071288 | Biological process | cellular response to mercury ion |
| GO_1903712 | Biological process | cysteine transmembrane transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0048678 | Biological process | response to axon injury |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0060013 | Biological process | righting reflex |
| GO_0006750 | Biological process | glutathione biosynthetic process |
| GO_0042883 | Biological process | cysteine transport |
| GO_0060047 | Biological process | heart contraction |
| GO_0090313 | Biological process | regulation of protein targeting to membrane |
| GO_0035633 | Biological process | maintenance of blood-brain barrier |
| GO_0072347 | Biological process | response to anesthetic |
| GO_0097049 | Biological process | motor neuron apoptotic process |
| GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
| GO_0048514 | Biological process | blood vessel morphogenesis |
| GO_0007215 | Biological process | glutamate receptor signaling pathway |
| GO_0007212 | Biological process | G protein-coupled dopamine receptor signaling pathway |
| GO_0071407 | Biological process | cellular response to organic cyclic compound |
| GO_0098793 | Cellular component | presynapse |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0045121 | Cellular component | membrane raft |
| GO_0043679 | Cellular component | axon terminus |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0009986 | Cellular component | cell surface |
| GO_0071944 | Cellular component | cell periphery |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0043198 | Cellular component | dendritic shaft |
| GO_0043204 | Cellular component | perikaryon |
| GO_1990635 | Cellular component | proximal dendrite |
| GO_0099544 | Cellular component | perisynaptic space |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0030424 | Cellular component | axon |
| GO_0097386 | Cellular component | glial cell projection |
| GO_0150002 | Cellular component | distal dendrite |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0032279 | Cellular component | asymmetric synapse |
| GO_0097440 | Cellular component | apical dendrite |
| GO_0043083 | Cellular component | synaptic cleft |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0016595 | Molecular function | glutamate binding |
| GO_0140010 | Molecular function | D-aspartate transmembrane transporter activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005253 | Molecular function | monoatomic anion channel activity |
| GO_0005314 | Molecular function | high-affinity L-glutamate transmembrane transporter activity |
| GO_0015108 | Molecular function | chloride transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0015501 | Molecular function | glutamate:sodium symporter activity |
| GO_0015183 | Molecular function | L-aspartate transmembrane transporter activity |
| GO_0033229 | Molecular function | cysteine transmembrane transporter activity |
| GO_0005313 | Molecular function | L-glutamate transmembrane transporter activity |
| Gene name | SLC1A1 |
| Protein name | Amino acid transporter Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) |
| Synonyms | EAAT3 HEAAC1 EAAC1 |
| Description | FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Can also transport L-cysteine . Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion . Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport . Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli . Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). . |
| Accessions | ENST00000422398.1 H0Y7R2 ENST00000262352.8 P43005 |
