SHMT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006544Biological processglycine metabolic process
GO_0006730Biological processone-carbon metabolic process
GO_0051289Biological processprotein homotetramerization
GO_0035999Biological processtetrahydrofolate interconversion
GO_0070129Biological processregulation of mitochondrial translation
GO_0019264Biological processglycine biosynthetic process from serine
GO_0051262Biological processprotein tetramerization
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0046653Biological processtetrahydrofolate metabolic process
GO_0002082Biological processregulation of oxidative phosphorylation
GO_1903715Biological processregulation of aerobic respiration
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006564Biological processL-serine biosynthetic process
GO_0034340Biological processresponse to type I interferon
GO_0006563Biological processL-serine metabolic process
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0005743Cellular componentmitochondrial inner membrane
GO_0070552Cellular componentBRISC complex
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0008732Molecular functionL-allo-threonine aldolase activity
GO_0004372Molecular functionglycine hydroxymethyltransferase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0003682Molecular functionchromatin binding
GO_0042802Molecular functionidentical protein binding
GO_0016597Molecular functionamino acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSHMT2
Protein nameSerine hydroxymethyltransferase 2
Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
Serine hydroxymethyltransferase 2 isoform 2
Serine hydroxymethyltransferase (EC 2.1.2.1)
glycine hydroxymethyltransferase (EC 2.1.2.1)
SynonymsHEL-S-51e
hCG_41231
DescriptionFUNCTION: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis . Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate . Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA . Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs . Associates with mitochondrial DNA . In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex . .

FUNCTION: Interconversion of serine and glycine. .

FUNCTION: Interconversion of serine and glycine. .

FUNCTION: Interconversion of serine and glycine. .

AccessionsENST00000557427.5
ENST00000449049.7 [P34897-3]
G3V3Y8
G3V4W5
G3V4T0
ENST00000555634.5
G3V540
ENST00000554604.5
ENST00000328923.8 [P34897-1]
V9HW06
ENST00000555774.5
Q5BJF5
P34897
H0YIZ0
ENST00000556737.1
ENST00000557703.5
ENST00000555116.5
ENST00000556689.5
ENST00000557487.5 [P34897-2]
G3V241
G3V2D2
G3V2Y4
ENST00000555563.5
ENST00000557529.1
ENST00000554975.5
ENST00000554310.5
ENST00000553529.5
G3V2E4
ENST00000553837.5
ENST00000557269.5
ENST00000556825.5
ENST00000557433.5
ENST00000553474.5 [P34897-3]
G3V2W0
ENST00000557348.5
G3V3C6
A0A0S2Z4J2
ENST00000414700.7 [P34897-3]
G3V2Y1
B4DLV4
ENST00000555773.5
G3V5L0
G3V4X0