SFXN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	19 studies	27% ± 10%	Explore
regulatory T cell	18 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	17 studies	28% ± 7%	Explore
T cell	15 studies	23% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	28% ± 6%	Explore
astrocyte	9 studies	32% ± 13%	Explore
glutamatergic neuron	8 studies	42% ± 25%	Explore
oligodendrocyte precursor cell	8 studies	29% ± 13%	Explore
GABAergic neuron	8 studies	34% ± 20%	Explore
natural killer cell	8 studies	24% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 6%	Explore
endothelial cell	7 studies	27% ± 11%	Explore
epithelial cell	7 studies	25% ± 6%	Explore
T follicular helper cell	7 studies	32% ± 11%	Explore
oligodendrocyte	7 studies	29% ± 6%	Explore
fibroblast	6 studies	21% ± 8%	Explore
gamma-delta T cell	6 studies	23% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
neuron	5 studies	29% ± 10%	Explore
amacrine cell	5 studies	26% ± 9%	Explore
basal cell	5 studies	25% ± 10%	Explore
retina horizontal cell	5 studies	36% ± 6%	Explore
adipocyte	5 studies	19% ± 6%	Explore
interneuron	5 studies	39% ± 22%	Explore
mucosal invariant T cell	5 studies	17% ± 1%	Explore
exhausted T cell	4 studies	27% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	27% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 7%	Explore
hepatocyte	4 studies	39% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	30% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	22% ± 3%	Explore
microglial cell	3 studies	18% ± 3%	Explore
retinal bipolar neuron	3 studies	21% ± 4%	Explore
retinal cone cell	3 studies	18% ± 2%	Explore
lymphocyte	3 studies	23% ± 6%	Explore
rod bipolar cell	3 studies	20% ± 3%	Explore
abnormal cell	3 studies	29% ± 7%	Explore
double negative thymocyte	3 studies	26% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	34% ± 19%	Explore
peripheral blood	7 studies	19% ± 2%	Explore
eye	4 studies	20% ± 6%	Explore
liver	3 studies	33% ± 5%	Explore
intestine	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1658.56	1445 / 1445	100%	28.37	183 / 183
stomach	100%	1295.06	359 / 359	100%	22.47	286 / 286
brain	100%	3388.68	2640 / 2642	100%	40.91	705 / 705
kidney	100%	3302.10	89 / 89	100%	29.86	900 / 901
uterus	100%	1668.04	170 / 170	100%	26.71	458 / 459
liver	100%	5284.64	226 / 226	100%	31.81	405 / 406
prostate	100%	2091.57	245 / 245	100%	17.66	500 / 502
intestine	100%	2006.81	966 / 966	99%	24.84	523 / 527
bladder	100%	1428.05	21 / 21	99%	24.33	500 / 504
lung	99%	1291.46	573 / 578	100%	27.34	1153 / 1155
breast	100%	1215.09	459 / 459	99%	24.53	1104 / 1118
thymus	100%	1552.07	652 / 653	99%	15.63	597 / 605
adrenal gland	100%	2829.26	258 / 258	98%	29.00	226 / 230
ovary	100%	2717.05	180 / 180	98%	15.06	421 / 430
pancreas	99%	905.14	324 / 328	99%	17.77	176 / 178
skin	100%	2295.77	1804 / 1809	91%	18.75	429 / 472
lymph node	0%	0	0 / 0	100%	33.07	29 / 29
spleen	100%	2040.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.11	45 / 45
ureter	0%	0	0 / 0	100%	8.07	1 / 1
adipose	99%	1136.30	1197 / 1204	0%	0	0 / 0
blood vessel	99%	1117.49	1324 / 1335	0%	0	0 / 0
heart	95%	1417.72	819 / 861	0%	0	0 / 0
muscle	94%	830.55	756 / 803	0%	0	0 / 0
peripheral blood	90%	2776.33	837 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	34%	3.23	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0015825	Biological process	L-serine transport
GO_0030218	Biological process	erythrocyte differentiation
GO_0140300	Biological process	serine import into mitochondrion
GO_0006730	Biological process	one-carbon metabolic process
GO_0015808	Biological process	L-alanine transport
GO_0006826	Biological process	iron ion transport
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0015180	Molecular function	L-alanine transmembrane transporter activity
GO_0015194	Molecular function	L-serine transmembrane transporter activity
GO_0015075	Molecular function	monoatomic ion transmembrane transporter activity
GO_0022857	Molecular function	transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SFXN1
Protein name	Sideroflexin 1 Sideroflexin-1
Synonyms
Description	FUNCTION: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors . May also transport other amino acids including alanine and cysteine . .
Accessions	ENST00000507017.5 D6RDG7 S4R2X2 ENST00000502393.5 D6RFI0 ENST00000321442.10 Q9H9B4 ENST00000506963.1 ENST00000502865.5 D6RAE9 H0Y9J5 ENST00000507823.5

SFXN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review