SCAF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000805Biological processnegative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0006369Biological processtermination of RNA polymerase II transcription
GO_0016363Cellular componentnuclear matrix
GO_0005849Cellular componentmRNA cleavage factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0043175Molecular functionRNA polymerase core enzyme binding
GO_1990269Molecular functionRNA polymerase II C-terminal domain phosphoserine binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSCAF8
Protein nameSR-related CTD associated factor 8
SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16)
SynonymsCCAP7
RBM16
KIAA1116
DescriptionFUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription . Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins . Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation . Independently of SCAF4, also acts as a positive regulator of transcript elongation . .

AccessionsENST00000367178.8 [Q9UPN6-1]
ENST00000417268.3
ENST00000367186.7 [Q9UPN6-2]
A0A0A0MT33
Q9UPN6