RUFY3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000114Biological processregulation of establishment of cell polarity
GO_0045773Biological processpositive regulation of axon extension
GO_0050771Biological processnegative regulation of axonogenesis
GO_0030335Biological processpositive regulation of cell migration
GO_0030154Biological processcell differentiation
GO_0007015Biological processactin filament organization
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0007399Biological processnervous system development
GO_0050770Biological processregulation of axonogenesis
GO_0012505Cellular componentendomembrane system
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0030175Cellular componentfilopodium
GO_0005829Cellular componentcytosol
GO_0070161Cellular componentanchoring junction
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRUFY3
Protein nameProtein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)
RUN and FYVE domain containing 3
SynonymsKIAA0871
DescriptionFUNCTION: Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery . Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner . .

AccessionsQ7L099
ENST00000502653.5 [Q7L099-4]
ENST00000381006.8 [Q7L099-3]
ENST00000513597.5
ENST00000503876.5
ENST00000514898.1
H0Y8I0
D6RCQ1
D6REM9
ENST00000417478.6 [Q7L099-2]
H0Y8G6
D6RH24
ENST00000226328.8 [Q7L099-1]
ENST00000512103.5
ENST00000504805.6