RTCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001890Biological processplacenta development
GO_0001701Biological processin utero embryonic development
GO_0006388Biological processtRNA splicing, via endonucleolytic cleavage and ligation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005635Cellular componentnuclear envelope
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0072669Cellular componenttRNA-splicing ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0003972Molecular functionRNA ligase (ATP) activity
GO_0017166Molecular functionvinculin binding
GO_0170057Molecular functionRNA ligase (GTP) activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRTCB
Protein nameRNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)
SynonymsHSPC117
C22orf28
DescriptionFUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. .

AccessionsENST00000216038.6
Q9Y3I0