Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 10 studies | 22% ± 7% | |
| B cell | 9 studies | 19% ± 6% | |
| endothelial cell | 9 studies | 24% ± 9% | |
| naive B cell | 6 studies | 19% ± 4% | |
| fibroblast | 6 studies | 23% ± 8% | |
| epithelial cell | 6 studies | 42% ± 14% | |
| natural killer cell | 6 studies | 20% ± 3% | |
| memory B cell | 6 studies | 17% ± 1% | |
| classical monocyte | 5 studies | 22% ± 6% | |
| non-classical monocyte | 5 studies | 24% ± 8% | |
| neuron | 5 studies | 26% ± 11% | |
| type I pneumocyte | 5 studies | 19% ± 4% | |
| goblet cell | 5 studies | 25% ± 6% | |
| basal cell | 5 studies | 28% ± 11% | |
| plasmacytoid dendritic cell | 5 studies | 22% ± 6% | |
| conventional dendritic cell | 4 studies | 30% ± 14% | |
| ciliated cell | 4 studies | 30% ± 7% | |
| glutamatergic neuron | 4 studies | 36% ± 15% | |
| microglial cell | 4 studies | 24% ± 5% | |
| oligodendrocyte precursor cell | 4 studies | 23% ± 4% | |
| CD8-positive, alpha-beta T cell | 4 studies | 17% ± 0% | |
| monocyte | 3 studies | 18% ± 3% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 2% | |
| CD4-positive, alpha-beta T cell | 3 studies | 19% ± 1% | |
| hematopoietic precursor cell | 3 studies | 33% ± 12% | |
| pericyte | 3 studies | 20% ± 3% | |
| smooth muscle cell | 3 studies | 19% ± 2% | |
| myeloid cell | 3 studies | 24% ± 8% | |
| endothelial cell of lymphatic vessel | 3 studies | 22% ± 6% | |
| retina horizontal cell | 3 studies | 22% ± 8% | |
| luminal hormone-sensing cell of mammary gland | 3 studies | 19% ± 1% | |
| GABAergic neuron | 3 studies | 31% ± 9% | |
| astrocyte | 3 studies | 21% ± 4% | |
| dendritic cell | 3 studies | 40% ± 13% | |
| abnormal cell | 3 studies | 21% ± 2% | |
| enterocyte | 3 studies | 21% ± 3% | |
| enteroendocrine cell | 3 studies | 23% ± 9% | |
| interneuron | 3 studies | 25% ± 13% | |
| oligodendrocyte | 3 studies | 23% ± 1% | |
| regulatory T cell | 3 studies | 17% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3840.24 | 1445 / 1445 | 100% | 75.11 | 183 / 183 |
| intestine | 100% | 4817.11 | 966 / 966 | 100% | 111.51 | 527 / 527 |
| lung | 100% | 3657.11 | 578 / 578 | 100% | 109.30 | 1155 / 1155 |
| prostate | 100% | 3889.25 | 245 / 245 | 100% | 118.61 | 502 / 502 |
| stomach | 100% | 3624.60 | 359 / 359 | 100% | 94.54 | 286 / 286 |
| breast | 100% | 4354.04 | 459 / 459 | 100% | 111.69 | 1116 / 1118 |
| uterus | 100% | 3994.89 | 170 / 170 | 100% | 101.57 | 458 / 459 |
| liver | 100% | 3137.04 | 226 / 226 | 100% | 77.45 | 405 / 406 |
| skin | 100% | 6522.58 | 1809 / 1809 | 99% | 128.96 | 469 / 472 |
| brain | 99% | 2634.47 | 2624 / 2642 | 100% | 105.23 | 705 / 705 |
| ovary | 100% | 3627.27 | 180 / 180 | 99% | 60.10 | 427 / 430 |
| kidney | 100% | 4228.84 | 89 / 89 | 99% | 85.76 | 894 / 901 |
| bladder | 100% | 3909.95 | 21 / 21 | 99% | 108.92 | 500 / 504 |
| pancreas | 99% | 2436.41 | 325 / 328 | 100% | 92.94 | 178 / 178 |
| thymus | 100% | 3564.31 | 653 / 653 | 99% | 92.94 | 598 / 605 |
| adrenal gland | 100% | 4108.86 | 258 / 258 | 94% | 70.99 | 216 / 230 |
| adipose | 100% | 3887.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4156.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 112.79 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 118.93 | 29 / 29 |
| muscle | 100% | 3841.45 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4142.27 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 135.52 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 62.33 | 1 / 1 |
| heart | 97% | 2708.84 | 832 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 2639.78 | 842 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001890 | Biological process | placenta development |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0006388 | Biological process | tRNA splicing, via endonucleolytic cleavage and ligation |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0072669 | Cellular component | tRNA-splicing ligase complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005525 | Molecular function | GTP binding |
| GO_0003972 | Molecular function | RNA ligase (ATP) activity |
| GO_0017166 | Molecular function | vinculin binding |
| GO_0170057 | Molecular function | RNA ligase (GTP) activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | RTCB |
| Protein name | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) |
| Synonyms | HSPC117 C22orf28 |
| Description | FUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. . |
| Accessions | ENST00000216038.6 Q9Y3I0 |