RNF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_0009617Biological processresponse to bacterium
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0031648Biological processprotein destabilization
GO_0070936Biological processprotein K48-linked ubiquitination
GO_2000785Biological processregulation of autophagosome assembly
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0030163Biological processprotein catabolic process
GO_0010507Biological processnegative regulation of autophagy
GO_0036503Biological processERAD pathway
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0044390Molecular functionubiquitin-like protein conjugating enzyme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF5
Protein nameE3 ubiquitin-protein ligase RNF (EC 2.3.2.27) (RING finger protein)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
SynonymsRMA1
hCG_1999929
NG2
G16
DescriptionFUNCTION: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins . May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 . Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin . Catalyzes ubiquitination of Salmonella type III secreted protein sopA . Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N . Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses . Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy . .

FUNCTION: E3 ubiquitin-protein ligase. .

FUNCTION: E3 ubiquitin-protein ligase. .

AccessionsENST00000445885.6
ENST00000472060.1
ENST00000456167.2
ENST00000453473.2
Q99942
ENST00000375094.4
ENST00000432616.2
ENST00000449794.2
ENST00000413786.2
A0A140TA09
A0A024RCQ4