RNF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0090234Biological processregulation of kinetochore assembly
GO_0051865Biological processprotein autoubiquitination
GO_0046685Biological processresponse to arsenic-containing substance
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0090169Biological processregulation of spindle assembly
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_1990752Cellular componentmicrotubule end
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0031491Molecular functionnucleosome binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0032184Molecular functionSUMO polymer binding

IV. Literature review

[source]
Gene nameRNF4
Protein nameRing finger protein 4
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
SynonymsRES4-26
SNURF
DescriptionFUNCTION: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation . Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 . Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation . Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 . Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation . Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 . .

AccessionsENST00000507247.5
D6RAD8
P78317
D6RA71
ENST00000314289.13 [P78317-1]
ENST00000513578.5
D6R9E0
ENST00000502316.5
D6RBQ7
ENST00000511600.5 [P78317-1]
ENST00000506706.5 [P78317-1]
ENST00000509258.5
D6RJF5
ENST00000504224.5
ENST00000511859.5 [P78317-2]
D6RBZ1
ENST00000541204.5 [P78317-2]
ENST00000513450.1