RNF126 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071629Biological processcytoplasm protein quality control by the ubiquitin-proteasome system
GO_0016567Biological processprotein ubiquitination
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0070534Biological processprotein K63-linked ubiquitination
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_0042127Biological processregulation of cell population proliferation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF126
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)
Ring finger protein 126
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins . Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome . May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor . May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination . By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation . May monoubiquitinate AICDA . .

AccessionsU3KQF4
K7EIY6
Q9BV68
ENST00000605891.5
ENST00000292363.10
ENST00000589762.5