RFX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0001675Biological processacrosome assembly
GO_0007286Biological processspermatid development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameRFX2
Protein nameDNA-binding protein RFX2 (Regulatory factor X 2)
Regulatory factor X2
RFX2_HUMAN, [AA 620-723]
Synonyms
DescriptionFUNCTION: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters . Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). .

AccessionsENST00000592281.5
ENST00000359161.7 [P48378-1]
K7EJE4
ENST00000592883.5
K7EQA0
ENST00000592473.5
ENST00000589742.5
ENST00000593241.5
ENST00000592546.5 [P48378-2]
ENST00000303657.10 [P48378-1]
K7EJD4
ENST00000587321.1
K7ELQ7
K7ENC9
K7EQU2
K7ES56
P48378
Q75MR3
ENST00000586806.1
K7ELD5
ENST00000589340.1
K7EIN5
ENST00000587181.1
ENST00000586302.5
K7EQY9