Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 38% ± 11% | |
astrocyte | 19 studies | 45% ± 19% | |
microglial cell | 16 studies | 55% ± 15% | |
oligodendrocyte | 15 studies | 44% ± 15% | |
oligodendrocyte precursor cell | 13 studies | 35% ± 11% | |
macrophage | 12 studies | 41% ± 14% | |
fibroblast | 10 studies | 30% ± 7% | |
pericyte | 9 studies | 34% ± 14% | |
adipocyte | 9 studies | 34% ± 13% | |
mast cell | 9 studies | 34% ± 9% | |
GABAergic neuron | 7 studies | 33% ± 15% | |
T cell | 7 studies | 31% ± 8% | |
B cell | 7 studies | 34% ± 11% | |
endothelial cell of lymphatic vessel | 7 studies | 36% ± 9% | |
smooth muscle cell | 6 studies | 30% ± 9% | |
monocyte | 6 studies | 37% ± 15% | |
glutamatergic neuron | 5 studies | 42% ± 16% | |
dendritic cell | 5 studies | 27% ± 7% | |
myeloid cell | 5 studies | 41% ± 7% | |
basal cell | 5 studies | 45% ± 22% | |
ciliated cell | 5 studies | 49% ± 19% | |
club cell | 5 studies | 44% ± 22% | |
interneuron | 4 studies | 35% ± 17% | |
mesothelial cell | 4 studies | 33% ± 13% | |
Mueller cell | 4 studies | 40% ± 13% | |
retinal cone cell | 4 studies | 35% ± 12% | |
retinal rod cell | 4 studies | 39% ± 10% | |
type I pneumocyte | 4 studies | 28% ± 4% | |
type II pneumocyte | 4 studies | 30% ± 6% | |
granule cell | 3 studies | 18% ± 3% | |
progenitor cell | 3 studies | 38% ± 9% | |
endothelial cell of vascular tree | 3 studies | 35% ± 7% | |
retinal pigment epithelial cell | 3 studies | 37% ± 25% | |
ependymal cell | 3 studies | 62% ± 7% | |
epithelial cell | 3 studies | 48% ± 20% | |
alveolar macrophage | 3 studies | 56% ± 11% | |
natural killer cell | 3 studies | 29% ± 6% | |
respiratory goblet cell | 3 studies | 49% ± 28% | |
lymphocyte | 3 studies | 35% ± 4% | |
leukocyte | 3 studies | 49% ± 6% | |
neuron | 3 studies | 51% ± 14% | |
mural cell | 3 studies | 42% ± 7% | |
mucus secreting cell | 3 studies | 33% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 370.61 | 459 / 459 | 97% | 4.20 | 1089 / 1118 |
thymus | 100% | 199.58 | 652 / 653 | 97% | 2.59 | 584 / 605 |
uterus | 100% | 782.26 | 170 / 170 | 95% | 3.11 | 435 / 459 |
skin | 100% | 297.40 | 1808 / 1809 | 95% | 2.81 | 447 / 472 |
bladder | 100% | 232.62 | 21 / 21 | 95% | 2.63 | 477 / 504 |
intestine | 100% | 176.32 | 966 / 966 | 94% | 2.30 | 496 / 527 |
esophagus | 99% | 138.32 | 1428 / 1445 | 95% | 2.46 | 174 / 183 |
lung | 100% | 172.90 | 577 / 578 | 92% | 2.48 | 1063 / 1155 |
ovary | 100% | 571.07 | 180 / 180 | 90% | 2.06 | 387 / 430 |
prostate | 100% | 228.71 | 244 / 245 | 90% | 1.99 | 451 / 502 |
stomach | 98% | 101.57 | 353 / 359 | 91% | 2.10 | 260 / 286 |
pancreas | 91% | 68.63 | 300 / 328 | 88% | 1.75 | 156 / 178 |
kidney | 99% | 151.28 | 88 / 89 | 79% | 1.57 | 712 / 901 |
brain | 88% | 99.56 | 2330 / 2642 | 86% | 1.62 | 604 / 705 |
adrenal gland | 100% | 153.31 | 257 / 258 | 31% | 0.50 | 71 / 230 |
adipose | 100% | 217.66 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 3.24 | 29 / 29 |
spleen | 100% | 202.30 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.01 | 1 / 1 |
blood vessel | 99% | 141.32 | 1317 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 2.33 | 44 / 45 |
peripheral blood | 95% | 248.34 | 887 / 929 | 0% | 0 | 0 / 0 |
liver | 73% | 48.46 | 166 / 226 | 20% | 0.32 | 80 / 406 |
eye | 0% | 0 | 0 / 0 | 91% | 2.38 | 73 / 80 |
heart | 75% | 59.03 | 649 / 861 | 0% | 0 | 0 / 0 |
muscle | 57% | 37.75 | 460 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001832 | Biological process | blastocyst growth |
GO_0006281 | Biological process | DNA repair |
GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
GO_0061053 | Biological process | somite development |
GO_0007131 | Biological process | reciprocal meiotic recombination |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0006310 | Biological process | DNA recombination |
GO_0005657 | Cellular component | replication fork |
GO_0005654 | Cellular component | nucleoplasm |
GO_0033063 | Cellular component | Rad51B-Rad51C-Rad51D-XRCC2 complex |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0140664 | Molecular function | ATP-dependent DNA damage sensor activity |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0000400 | Molecular function | four-way junction DNA binding |
GO_0005524 | Molecular function | ATP binding |
GO_0008094 | Molecular function | ATP-dependent activity, acting on DNA |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | RAD51B |
Protein name | RAD51 paralog B DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) |
Synonyms | REC2 RAD51L1 |
Description | FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. . |
Accessions | C9JYJ0 G3V4W9 ENST00000488612.5 [O15315-4] ENST00000460526.6 [O15315-1] ENST00000479335.5 ENST00000485181.5 ENST00000554575.2 ENST00000553334.1 ENST00000471583.6 [O15315-2] F8WAY6 H0YJI5 O15315 ENST00000487861.5 ENST00000487270.5 [O15315-3] C9J5S9 |