RAD51B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001832Biological processblastocyst growth
GO_0006281Biological processDNA repair
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0061053Biological processsomite development
GO_0007131Biological processreciprocal meiotic recombination
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006310Biological processDNA recombination
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0033063Cellular componentRad51B-Rad51C-Rad51D-XRCC2 complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0005524Molecular functionATP binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRAD51B
Protein nameRAD51 paralog B
DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)
SynonymsREC2
RAD51L1
DescriptionFUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. .

AccessionsC9JYJ0
G3V4W9
ENST00000488612.5 [O15315-4]
ENST00000460526.6 [O15315-1]
ENST00000479335.5
ENST00000485181.5
ENST00000554575.2
ENST00000553334.1
ENST00000471583.6 [O15315-2]
F8WAY6
H0YJI5
O15315
ENST00000487861.5
ENST00000487270.5 [O15315-3]
C9J5S9