RAB13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0032869Biological processcellular response to insulin stimulus
GO_0031175Biological processneuron projection development
GO_0010737Biological processprotein kinase A signaling
GO_0097368Biological processestablishment of Sertoli cell barrier
GO_0032456Biological processendocytic recycling
GO_0009306Biological processprotein secretion
GO_0035767Biological processendothelial cell chemotaxis
GO_0016197Biological processendosomal transport
GO_0006887Biological processexocytosis
GO_0070830Biological processbicellular tight junction assembly
GO_1902463Biological processprotein localization to cell leading edge
GO_0006893Biological processGolgi to plasma membrane transport
GO_0044795Biological processtrans-Golgi network to recycling endosome transport
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0030139Cellular componentendocytic vesicle
GO_0055037Cellular componentrecycling endosome
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0032593Cellular componentinsulin-responsive compartment
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0030054Cellular componentcell junction
GO_0005768Cellular componentendosome
GO_0030027Cellular componentlamellipodium
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB13
Protein nameRAB13, member RAS oncogene family
Ras-related protein Rab-13
Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)
SynonymsGIG4
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. .

AccessionsENST00000614713.4
P51153
Q504R6
ENST00000368575.5
A0A087WWB9