R3HDM4 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
regulatory T cell	17 studies	28% ± 8%	Explore
B cell	14 studies	25% ± 6%	Explore
CD4-positive, alpha-beta T cell	14 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	13 studies	20% ± 4%	Explore
memory B cell	11 studies	27% ± 7%	Explore
naive B cell	10 studies	22% ± 3%	Explore
platelet	9 studies	30% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	26% ± 5%	Explore
classical monocyte	9 studies	24% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 6%	Explore
erythrocyte	8 studies	44% ± 13%	Explore
T cell	8 studies	21% ± 2%	Explore
gamma-delta T cell	8 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	30% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	25% ± 8%	Explore
mucosal invariant T cell	7 studies	21% ± 2%	Explore
neutrophil	6 studies	26% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	17% ± 2%	Explore
natural killer cell	5 studies	18% ± 2%	Explore
conventional dendritic cell	4 studies	34% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
epithelial cell	4 studies	32% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 3%	Explore
ciliated cell	4 studies	21% ± 3%	Explore
T follicular helper cell	4 studies	22% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 5%	Explore
hematopoietic stem cell	4 studies	31% ± 17%	Explore
exhausted T cell	3 studies	28% ± 7%	Explore
non-classical monocyte	3 studies	29% ± 3%	Explore
megakaryocyte	3 studies	36% ± 16%	Explore
immature B cell	3 studies	26% ± 6%	Explore
endothelial cell	3 studies	18% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	17% ± 0%	Explore
dendritic cell	3 studies	37% ± 16%	Explore
abnormal cell	3 studies	20% ± 2%	Explore
basal cell	3 studies	25% ± 7%	Explore
goblet cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	24% ± 4%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3443.87	966 / 966	100%	118.88	527 / 527
ovary	100%	2020.32	180 / 180	100%	62.69	430 / 430
pancreas	100%	2510.78	328 / 328	100%	127.17	178 / 178
uterus	100%	2828.18	170 / 170	100%	117.26	459 / 459
esophagus	100%	4142.29	1444 / 1445	100%	97.08	183 / 183
thymus	100%	3129.37	652 / 653	100%	85.33	605 / 605
bladder	100%	3823.38	21 / 21	100%	119.67	503 / 504
prostate	100%	3995.86	245 / 245	100%	91.40	501 / 502
skin	100%	4124.50	1809 / 1809	100%	89.96	471 / 472
stomach	100%	2780.48	359 / 359	100%	107.28	285 / 286
brain	99%	2714.68	2628 / 2642	100%	70.40	705 / 705
lung	100%	5315.52	577 / 578	99%	103.77	1149 / 1155
breast	100%	3406.28	459 / 459	99%	102.51	1110 / 1118
liver	100%	2402.39	226 / 226	99%	55.15	403 / 406
kidney	100%	3779.19	89 / 89	99%	57.09	893 / 901
adrenal gland	100%	2231.12	258 / 258	98%	46.50	226 / 230
adipose	100%	3164.07	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	75.48	80 / 80
lymph node	0%	0	0 / 0	100%	168.24	29 / 29
peripheral blood	100%	43556.45	929 / 929	0%	0	0 / 0
spleen	100%	8520.31	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	122.89	45 / 45
ureter	0%	0	0 / 0	100%	77.17	1 / 1
blood vessel	100%	2596.45	1333 / 1335	0%	0	0 / 0
muscle	100%	2791.87	799 / 803	0%	0	0 / 0
heart	97%	1776.78	837 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0