PTPRE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0005634Cellular componentnucleus
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005001Molecular functiontransmembrane receptor protein tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRE
Protein nameProtein tyrosine phosphatase receptor type E
PTPRE
Tyrosine phosphatase epsilon PD1
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Synonyms
DescriptionFUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). .; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). .; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). .

AccessionsS4R2Y5
ENST00000471218.5
Q5VWH5
ENST00000467366.1
ENST00000495530.5
ENST00000455661.5
ENST00000254667.8 [P23469-1]
ENST00000442830.5
Q8TE48
Q96P81
ENST00000479896.1
P23469
Q5VWH6
ENST00000306042.9 [P23469-2]
S4R3X3
S4R448
S4R3B0