PSMD14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0045471Biological processresponse to ethanol
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0016579Biological processprotein deubiquitination
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0031597Cellular componentcytosolic proteasome complex
GO_0008541Cellular componentproteasome regulatory particle, lid subcomplex
GO_0022624Cellular componentproteasome accessory complex
GO_0005634Cellular componentnucleus
GO_0140492Molecular functionmetal-dependent deubiquitinase activity
GO_0070628Molecular functionproteasome binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0061133Molecular functionendopeptidase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMD14
Protein nameProteasome 26S subunit, non-ATPase 14
Uncharacterized protein PSMD14
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)
SynonymsPOH1
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. .

AccessionsC9JW37
Q53TH1
O00487
ENST00000409682.8
Q4ZG77
ENST00000437630.1