PLAAT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009617Biological processresponse to bacterium
GO_0036152Biological processphosphatidylethanolamine acyl-chain remodeling
GO_0016042Biological processlipid catabolic process
GO_0008654Biological processphospholipid biosynthetic process
GO_1903008Biological processorganelle disassembly
GO_0007031Biological processperoxisome organization
GO_0006641Biological processtriglyceride metabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0070306Biological processlens fiber cell differentiation
GO_1904177Biological processregulation of adipose tissue development
GO_0030397Biological processmembrane disassembly
GO_0070292Biological processN-acylphosphatidylethanolamine metabolic process
GO_0046485Biological processether lipid metabolic process
GO_0005778Cellular componentperoxisomal membrane
GO_0005575Cellular componentcellular_component
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005764Cellular componentlysosome
GO_0005777Cellular componentperoxisome
GO_0005635Cellular componentnuclear envelope
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0008970Molecular functionphospholipase A1 activity
GO_0052739Molecular functionphosphatidylserine 1-acylhydrolase activity
GO_0052740Molecular function1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO_0008289Molecular functionlipid binding
GO_0004623Molecular functionphospholipase A2 activity
GO_0016746Molecular functionacyltransferase activity
GO_0016410Molecular functionN-acyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLAAT3
Protein namePhospholipase A and acyltransferase 3
Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65)
PLA2G16 protein
SynonymsHRASLS3
HREV107
PLA2G16
DescriptionFUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) . Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity . Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity). .; FUNCTION: (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm . May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection . Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome . May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery . The lipid-modifying enzyme activity is required for this process . .

AccessionsP53816
ENST00000540943.1
ENST00000323646.9
ENST00000415826.3
F5H7E5
Q3MI98