PKD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	18 studies	29% ± 10%	Explore
endothelial cell	16 studies	27% ± 13%	Explore
oligodendrocyte	15 studies	42% ± 17%	Explore
oligodendrocyte precursor cell	13 studies	40% ± 19%	Explore
astrocyte	13 studies	29% ± 10%	Explore
smooth muscle cell	11 studies	27% ± 10%	Explore
microglial cell	11 studies	37% ± 12%	Explore
GABAergic neuron	10 studies	45% ± 23%	Explore
glutamatergic neuron	10 studies	48% ± 25%	Explore
adipocyte	7 studies	31% ± 8%	Explore
interneuron	6 studies	48% ± 21%	Explore
macrophage	6 studies	30% ± 10%	Explore
myofibroblast cell	6 studies	25% ± 13%	Explore
pericyte	6 studies	31% ± 10%	Explore
neuron	4 studies	41% ± 16%	Explore
granule cell	4 studies	29% ± 3%	Explore
mesothelial cell	4 studies	47% ± 18%	Explore
epithelial cell	4 studies	29% ± 9%	Explore
Mueller cell	4 studies	33% ± 10%	Explore
retina horizontal cell	4 studies	25% ± 5%	Explore
ciliated cell	4 studies	20% ± 5%	Explore
GABAergic interneuron	3 studies	36% ± 2%	Explore
glial cell	3 studies	22% ± 4%	Explore
GABAergic amacrine cell	3 studies	22% ± 5%	Explore
amacrine cell	3 studies	25% ± 4%	Explore
glycinergic amacrine cell	3 studies	24% ± 8%	Explore
retinal cone cell	3 studies	20% ± 5%	Explore
endothelial cell of vascular tree	3 studies	27% ± 12%	Explore
connective tissue cell	3 studies	18% ± 0%	Explore
adventitial cell	3 studies	26% ± 7%	Explore
alveolar macrophage	3 studies	29% ± 9%	Explore
basal cell	3 studies	30% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	41% ± 22%	Explore
adipose	3 studies	27% ± 9%	Explore
heart	3 studies	21% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	3845.17	89 / 89	100%	72.35	897 / 901
lung	100%	5246.08	576 / 578	97%	20.25	1126 / 1155
thymus	100%	3818.55	651 / 653	95%	20.57	577 / 605
prostate	99%	4019.48	243 / 245	96%	20.47	481 / 502
breast	100%	4912.37	459 / 459	94%	18.55	1048 / 1118
skin	96%	3269.40	1730 / 1809	97%	39.98	458 / 472
adrenal gland	100%	4186.00	257 / 258	93%	17.39	214 / 230
esophagus	96%	5302.95	1391 / 1445	95%	18.78	174 / 183
uterus	100%	13788.02	170 / 170	90%	15.71	414 / 459
ovary	100%	6866.55	180 / 180	90%	11.79	385 / 430
bladder	100%	5173.43	21 / 21	88%	13.10	443 / 504
brain	88%	1911.28	2319 / 2642	99%	20.94	695 / 705
pancreas	82%	1565.13	270 / 328	97%	28.73	173 / 178
intestine	97%	5663.15	935 / 966	78%	11.34	413 / 527
stomach	79%	4239.91	284 / 359	85%	14.95	243 / 286
adipose	100%	6993.61	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16661.58	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.04	1 / 1
spleen	96%	1877.98	232 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	96%	51.58	77 / 80
tonsil	0%	0	0 / 0	93%	11.82	42 / 45
heart	90%	2444.86	773 / 861	0%	0	0 / 0
liver	35%	526.84	78 / 226	53%	8.08	214 / 406
lymph node	0%	0	0 / 0	66%	7.99	19 / 29
muscle	23%	353.77	184 / 803	0%	0	0 / 0
peripheral blood	16%	274.21	151 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071910	Biological process	determination of liver left/right asymmetry
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0021510	Biological process	spinal cord development
GO_0071498	Biological process	cellular response to fluid shear stress
GO_0001947	Biological process	heart looping
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0072235	Biological process	metanephric distal tubule development
GO_0031587	Biological process	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO_0051262	Biological process	protein tetramerization
GO_0061441	Biological process	renal artery morphogenesis
GO_0071320	Biological process	cellular response to cAMP
GO_0072075	Biological process	metanephric mesenchyme development
GO_0060674	Biological process	placenta blood vessel development
GO_0071464	Biological process	cellular response to hydrostatic pressure
GO_0051290	Biological process	protein heterotetramerization
GO_0003127	Biological process	detection of nodal flow
GO_0006816	Biological process	calcium ion transport
GO_0051726	Biological process	regulation of cell cycle
GO_0035502	Biological process	metanephric part of ureteric bud development
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0060315	Biological process	negative regulation of ryanodine-sensitive calcium-release channel activity
GO_0035904	Biological process	aorta development
GO_0072164	Biological process	mesonephric tubule development
GO_0001892	Biological process	embryonic placenta development
GO_0007368	Biological process	determination of left/right symmetry
GO_0010628	Biological process	positive regulation of gene expression
GO_0050982	Biological process	detection of mechanical stimulus
GO_0071277	Biological process	cellular response to calcium ion
GO_0072218	Biological process	metanephric ascending thin limb development
GO_0071470	Biological process	cellular response to osmotic stress
GO_0044782	Biological process	cilium organization
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0007259	Biological process	cell surface receptor signaling pathway via JAK-STAT
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0051289	Biological process	protein homotetramerization
GO_0090279	Biological process	regulation of calcium ion import
GO_0072214	Biological process	metanephric cortex development
GO_0061333	Biological process	renal tubule morphogenesis
GO_0019722	Biological process	calcium-mediated signaling
GO_0051298	Biological process	centrosome duplication
GO_0001889	Biological process	liver development
GO_0098662	Biological process	inorganic cation transmembrane transport
GO_0072219	Biological process	metanephric cortical collecting duct development
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0016055	Biological process	Wnt signaling pathway
GO_0042127	Biological process	regulation of cell population proliferation
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0072208	Biological process	metanephric smooth muscle tissue development
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0007507	Biological process	heart development
GO_0072284	Biological process	metanephric S-shaped body morphogenesis
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0051649	Biological process	establishment of localization in cell
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0021915	Biological process	neural tube development
GO_0072177	Biological process	mesonephric duct development
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0002133	Cellular component	polycystin complex
GO_0016323	Cellular component	basolateral plasma membrane
GO_0072686	Cellular component	mitotic spindle
GO_0045180	Cellular component	basal cortex
GO_0070062	Cellular component	extracellular exosome
GO_0060170	Cellular component	ciliary membrane
GO_0097730	Cellular component	non-motile cilium
GO_0140494	Cellular component	migrasome
GO_0030027	Cellular component	lamellipodium
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031514	Cellular component	motile cilium
GO_0005794	Cellular component	Golgi apparatus
GO_0005929	Cellular component	cilium
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0036064	Cellular component	ciliary basal body
GO_0098554	Cellular component	cytoplasmic side of endoplasmic reticulum membrane
GO_0005911	Cellular component	cell-cell junction
GO_0098553	Cellular component	lumenal side of endoplasmic reticulum membrane
GO_0005829	Cellular component	cytosol
GO_0034703	Cellular component	cation channel complex
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0048763	Molecular function	calcium-induced calcium release activity
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0022843	Molecular function	voltage-gated monoatomic cation channel activity
GO_0042802	Molecular function	identical protein binding
GO_0051117	Molecular function	ATPase binding
GO_0005509	Molecular function	calcium ion binding
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005261	Molecular function	monoatomic cation channel activity
GO_0005267	Molecular function	potassium channel activity
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0005245	Molecular function	voltage-gated calcium channel activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0005262	Molecular function	calcium channel activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0015271	Molecular function	outward rectifier potassium channel activity
GO_0005244	Molecular function	voltage-gated monoatomic ion channel activity
GO_0051371	Molecular function	muscle alpha-actinin binding
GO_0042805	Molecular function	actinin binding
GO_0051219	Molecular function	phosphoprotein binding
GO_0043398	Molecular function	HLH domain binding

IV. Literature review

[source]

Gene name	PKD2
Protein name	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) Polycystic kidney disease 2 related protein PC-2 mutant Polycystin-2 PC-2
Synonyms	TRPP2
Description	FUNCTION: Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B . Can also form a functional, homotetrameric ion channel . Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium . Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) . May contribute to the release of Ca(2+) stores from the endoplasmic reticulum . Together with TRPV4, forms mechano- and thermosensitive channels in cilium . PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity). .
Accessions	ENST00000237596.7 [Q13563-1] ENST00000502363.1 Q13563 A0A0C5GN91 B4DFN3 A0A0C5G176 O95814 ENST00000508588.5

PKD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review