PHACTR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061386Biological processclosure of optic fissure
GO_0007266Biological processRho protein signal transduction
GO_2001045Biological processnegative regulation of integrin-mediated signaling pathway
GO_0030036Biological processactin cytoskeleton organization
GO_0001843Biological processneural tube closure
GO_0001755Biological processneural crest cell migration
GO_0043085Biological processpositive regulation of catalytic activity
GO_0051726Biological processregulation of cell cycle
GO_0048484Biological processenteric nervous system development
GO_0030027Cellular componentlamellipodium
GO_0005737Cellular componentcytoplasm
GO_0072542Molecular functionprotein phosphatase activator activity
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePHACTR4
Protein namePhosphatase and actin regulator 4
SynonymsPRO2963
DescriptionFUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). .

FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway. .

FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway. .

AccessionsENST00000373836.4 [Q8IZ21-2]
Q8IZ21
A0A0J9YVR0
A0A0J9YY52
ENST00000632421.1
A0A0J9YWV8
ENST00000493669.2 [Q8IZ21-4]
ENST00000632202.1
ENST00000373839.8 [Q8IZ21-1]
ENST00000633167.1