PDE7A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	22 studies	31% ± 16%	Explore
T cell	16 studies	31% ± 14%	Explore
natural killer cell	15 studies	25% ± 11%	Explore
CD4-positive, alpha-beta T cell	12 studies	30% ± 14%	Explore
astrocyte	12 studies	28% ± 12%	Explore
microglial cell	11 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	11 studies	27% ± 12%	Explore
glutamatergic neuron	10 studies	40% ± 25%	Explore
oligodendrocyte precursor cell	10 studies	33% ± 15%	Explore
oligodendrocyte	10 studies	37% ± 13%	Explore
endothelial cell	9 studies	30% ± 13%	Explore
fibroblast	9 studies	28% ± 8%	Explore
macrophage	8 studies	31% ± 6%	Explore
GABAergic neuron	8 studies	43% ± 20%	Explore
memory B cell	7 studies	20% ± 4%	Explore
naive B cell	7 studies	24% ± 4%	Explore
epithelial cell	7 studies	29% ± 13%	Explore
dendritic cell	7 studies	31% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	26% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	33% ± 15%	Explore
interneuron	6 studies	46% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	35% ± 14%	Explore
adipocyte	6 studies	31% ± 15%	Explore
cardiac muscle cell	6 studies	68% ± 22%	Explore
mucosal invariant T cell	6 studies	28% ± 16%	Explore
regulatory T cell	6 studies	27% ± 11%	Explore
leukocyte	6 studies	37% ± 25%	Explore
neuron	5 studies	45% ± 18%	Explore
myeloid cell	5 studies	26% ± 9%	Explore
gamma-delta T cell	5 studies	28% ± 11%	Explore
monocyte	5 studies	26% ± 5%	Explore
type I pneumocyte	5 studies	28% ± 7%	Explore
type II pneumocyte	5 studies	24% ± 7%	Explore
hematopoietic precursor cell	4 studies	26% ± 6%	Explore
lymphocyte	4 studies	62% ± 20%	Explore
retinal cone cell	4 studies	23% ± 4%	Explore
retinal rod cell	4 studies	24% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 5%	Explore
mature NK T cell	4 studies	28% ± 15%	Explore
basal cell	4 studies	49% ± 21%	Explore
ciliated cell	4 studies	29% ± 8%	Explore
club cell	4 studies	33% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	41% ± 10%	Explore
GABAergic interneuron	3 studies	28% ± 8%	Explore
granule cell	3 studies	24% ± 5%	Explore
progenitor cell	3 studies	32% ± 0%	Explore
plasma cell	3 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	24% ± 7%	Explore
GABAergic amacrine cell	3 studies	26% ± 7%	Explore
Mueller cell	3 studies	32% ± 7%	Explore
alveolar macrophage	3 studies	36% ± 9%	Explore
endothelial cell of lymphatic vessel	3 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 8%	Explore
pericyte	3 studies	25% ± 7%	Explore
plasmacytoid dendritic cell	3 studies	25% ± 7%	Explore
smooth muscle cell	3 studies	29% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	38% ± 20%	Explore
lung	5 studies	25% ± 7%	Explore
heart	4 studies	42% ± 11%	Explore
eye	4 studies	30% ± 6%	Explore
liver	4 studies	22% ± 9%	Explore
peripheral blood	3 studies	22% ± 6%	Explore
adipose	3 studies	20% ± 2%	Explore
kidney	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3252.50	578 / 578	99%	12.16	1139 / 1155
breast	99%	2213.71	454 / 459	99%	17.02	1112 / 1118
prostate	100%	2454.98	244 / 245	99%	10.22	495 / 502
uterus	99%	1324.32	169 / 170	98%	13.29	452 / 459
thymus	100%	4187.82	653 / 653	95%	15.17	577 / 605
esophagus	95%	955.38	1369 / 1445	100%	14.41	183 / 183
kidney	100%	1724.26	89 / 89	95%	10.86	853 / 901
stomach	99%	1614.11	357 / 359	94%	8.57	270 / 286
pancreas	100%	1359.16	327 / 328	94%	10.55	167 / 178
intestine	97%	1838.25	939 / 966	92%	7.48	487 / 527
ovary	97%	958.36	175 / 180	92%	8.77	397 / 430
bladder	90%	1464.62	19 / 21	97%	11.49	487 / 504
brain	91%	1090.93	2416 / 2642	91%	5.84	642 / 705
skin	99%	1290.26	1782 / 1809	80%	6.12	376 / 472
lymph node	0%	0	0 / 0	100%	23.97	29 / 29
muscle	100%	5432.16	803 / 803	0%	0	0 / 0
spleen	100%	5005.48	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	11.55	45 / 45
ureter	0%	0	0 / 0	100%	9.57	1 / 1
adipose	98%	1440.30	1180 / 1204	0%	0	0 / 0
heart	97%	4791.89	839 / 861	0%	0	0 / 0
peripheral blood	97%	3663.56	900 / 929	0%	0	0 / 0
liver	44%	296.83	99 / 226	35%	2.74	142 / 406
blood vessel	71%	633.07	953 / 1335	0%	0	0 / 0
adrenal gland	42%	260.90	109 / 258	22%	1.15	51 / 230
eye	0%	0	0 / 0	59%	3.90	47 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019933	Biological process	cAMP-mediated signaling
GO_0006198	Biological process	cAMP catabolic process
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005634	Cellular component	nucleus
GO_0047555	Molecular function	3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115	Molecular function	3',5'-cyclic-AMP phosphodiesterase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	PDE7A
Protein name	Phosphodiesterase 7A High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A)
Synonyms
Description	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May have a role in muscle signal transduction . .
Accessions	Q13946 Q7Z7I0 ENST00000396642.7 [Q13946-3] ENST00000523253.1 ENST00000401827.8 [Q13946-1] E5RG23 ENST00000379419.8 [Q13946-2]

PDE7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review