ORMDL3 | OmnibusX

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	9 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	24% ± 7%	Explore
regulatory T cell	6 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 3%	Explore
gamma-delta T cell	5 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	17% ± 1%	Explore
plasma cell	4 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	23% ± 3%	Explore
epithelial cell	3 studies	26% ± 7%	Explore
T follicular helper cell	3 studies	20% ± 4%	Explore
goblet cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	20% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ORMDL3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	11923.80	226 / 226	100%	170.01	406 / 406
pancreas	100%	4453.38	328 / 328	100%	81.43	178 / 178
prostate	100%	4052.57	245 / 245	100%	113.20	502 / 502
thymus	100%	5008.32	653 / 653	100%	189.30	604 / 605
bladder	100%	3521.38	21 / 21	100%	103.44	503 / 504
uterus	100%	3372.36	170 / 170	100%	73.36	458 / 459
brain	100%	2838.10	2639 / 2642	100%	73.36	704 / 705
lung	100%	3456.37	578 / 578	100%	82.44	1151 / 1155
stomach	100%	3465.63	359 / 359	100%	65.25	285 / 286
breast	100%	7058.80	459 / 459	99%	173.92	1112 / 1118
intestine	100%	3422.37	966 / 966	99%	79.29	522 / 527
skin	100%	3435.35	1809 / 1809	99%	51.16	466 / 472
kidney	100%	3329.20	89 / 89	97%	48.35	878 / 901
adrenal gland	100%	2835.73	258 / 258	97%	58.97	223 / 230
esophagus	100%	2734.88	1445 / 1445	89%	41.59	162 / 183
ovary	100%	3443.62	180 / 180	77%	28.15	333 / 430
adipose	100%	7468.51	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	88.46	29 / 29
spleen	100%	3678.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	67.18	45 / 45
ureter	0%	0	0 / 0	100%	137.89	1 / 1
blood vessel	100%	2771.96	1329 / 1335	0%	0	0 / 0
heart	98%	2500.85	848 / 861	0%	0	0 / 0
muscle	98%	1718.16	790 / 803	0%	0	0 / 0
peripheral blood	98%	2969.70	913 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	41.78	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0030148	Biological process	sphingolipid biosynthetic process
GO_0006940	Biological process	regulation of smooth muscle contraction
GO_0002903	Biological process	negative regulation of B cell apoptotic process
GO_0006672	Biological process	ceramide metabolic process
GO_0090156	Biological process	intracellular sphingolipid homeostasis
GO_0006686	Biological process	sphingomyelin biosynthetic process
GO_0010508	Biological process	positive regulation of autophagy
GO_0042552	Biological process	myelination
GO_1900060	Biological process	negative regulation of ceramide biosynthetic process
GO_0061744	Biological process	motor behavior
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0017059	Cellular component	serine palmitoyltransferase complex
GO_0030667	Cellular component	secretory granule membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

Gene name	ORMDL3
Protein name	HSPC209 (ORM1-like 3 (S. cerevisiae), isoform CRA_a) ORM1-like protein 3
Synonyms	hCG_30021
Description	FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels . When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis . .
Accessions	ENST00000584220.5 [Q8N138-4] Q8N138 ENST00000304046.7 [Q8N138-1] Q9P0R7 J3KTF9 ENST00000584000.1 ENST00000581284.5 J3QRM9 ENST00000579695.5 [Q8N138-1] ENST00000394169.5 [Q8N138-1]

ORMDL3 report