NUDT5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019303Biological processD-ribose catabolic process
GO_0019693Biological processribose phosphate metabolic process
GO_0009117Biological processnucleotide metabolic process
GO_0055086Biological processnucleobase-containing small molecule metabolic process
GO_0009191Biological processribonucleoside diphosphate catabolic process
GO_0006338Biological processchromatin remodeling
GO_0006753Biological processnucleoside phosphate metabolic process
GO_1990966Biological processATP generation from poly-ADP-D-ribose
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0019144Molecular functionADP-sugar diphosphatase activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0044715Molecular function8-oxo-dGDP phosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0044716Molecular function8-oxo-GDP phosphatase activity
GO_0030515Molecular functionsnoRNA binding
GO_0047631Molecular functionADP-ribose diphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUDT5
Protein nameADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)
Nudix hydrolase 5
SynonymsHSPC115
NUDIX5
DescriptionFUNCTION: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate . In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP . Can also hydrolyze other nucleotide sugars with low activity . In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming . Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). .

AccessionsA6NCQ0
ENST00000378937.7
ENST00000378940.7
ENST00000378927.7
A6NJU6
Q9UKK9
ENST00000491614.6
C9JYY9
ENST00000444732.1
H0YEY4
ENST00000476462.5
A6NFX8