Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 31% ± 11% | |
oligodendrocyte precursor cell | 13 studies | 35% ± 17% | |
fibroblast | 12 studies | 32% ± 10% | |
macrophage | 12 studies | 32% ± 16% | |
oligodendrocyte | 12 studies | 35% ± 14% | |
microglial cell | 12 studies | 34% ± 13% | |
astrocyte | 11 studies | 36% ± 17% | |
pericyte | 9 studies | 27% ± 10% | |
smooth muscle cell | 7 studies | 28% ± 6% | |
type I pneumocyte | 7 studies | 34% ± 17% | |
epithelial cell | 7 studies | 36% ± 18% | |
adipocyte | 7 studies | 35% ± 11% | |
myeloid cell | 6 studies | 23% ± 6% | |
dendritic cell | 6 studies | 23% ± 5% | |
mast cell | 6 studies | 23% ± 9% | |
mesothelial cell | 6 studies | 37% ± 12% | |
ciliated cell | 6 studies | 30% ± 12% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 23% ± 7% | |
cardiac muscle cell | 5 studies | 57% ± 16% | |
T cell | 5 studies | 27% ± 9% | |
endothelial cell of lymphatic vessel | 5 studies | 31% ± 11% | |
monocyte | 5 studies | 32% ± 6% | |
type II pneumocyte | 5 studies | 27% ± 9% | |
GABAergic neuron | 4 studies | 33% ± 7% | |
B cell | 4 studies | 25% ± 6% | |
CD4-positive, alpha-beta T cell | 4 studies | 27% ± 6% | |
endothelial cell of artery | 4 studies | 20% ± 3% | |
mucosal invariant T cell | 4 studies | 26% ± 8% | |
lymphocyte | 4 studies | 37% ± 20% | |
retinal rod cell | 4 studies | 34% ± 10% | |
regulatory T cell | 4 studies | 21% ± 6% | |
glutamatergic neuron | 4 studies | 36% ± 4% | |
club cell | 4 studies | 31% ± 12% | |
natural killer cell | 4 studies | 27% ± 6% | |
basal cell | 4 studies | 36% ± 25% | |
neuron | 4 studies | 39% ± 21% | |
glial cell | 3 studies | 20% ± 2% | |
CD8-positive, alpha-beta T cell | 3 studies | 29% ± 4% | |
mononuclear phagocyte | 3 studies | 21% ± 5% | |
vein endothelial cell | 3 studies | 34% ± 18% | |
endothelial cell of vascular tree | 3 studies | 36% ± 23% | |
hepatocyte | 3 studies | 35% ± 10% | |
retinal pigment epithelial cell | 3 studies | 31% ± 19% | |
neural progenitor cell | 3 studies | 28% ± 2% | |
connective tissue cell | 3 studies | 18% ± 3% | |
ependymal cell | 3 studies | 35% ± 10% | |
alveolar macrophage | 3 studies | 34% ± 11% | |
capillary endothelial cell | 3 studies | 29% ± 8% | |
respiratory goblet cell | 3 studies | 32% ± 12% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 18% ± 4% | |
mural cell | 3 studies | 43% ± 14% | |
mucus secreting cell | 3 studies | 25% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 3591.00 | 180 / 180 | 100% | 35.49 | 430 / 430 |
lung | 100% | 5532.97 | 578 / 578 | 100% | 44.15 | 1154 / 1155 |
esophagus | 100% | 4251.26 | 1443 / 1445 | 100% | 59.16 | 183 / 183 |
breast | 100% | 4678.74 | 459 / 459 | 99% | 45.52 | 1105 / 1118 |
intestine | 100% | 4669.12 | 965 / 966 | 98% | 31.76 | 514 / 527 |
uterus | 100% | 4540.94 | 170 / 170 | 97% | 34.41 | 447 / 459 |
thymus | 100% | 3267.30 | 651 / 653 | 98% | 30.62 | 591 / 605 |
prostate | 100% | 3368.47 | 244 / 245 | 97% | 30.13 | 489 / 502 |
bladder | 100% | 4649.48 | 21 / 21 | 97% | 31.96 | 488 / 504 |
adrenal gland | 100% | 7747.45 | 258 / 258 | 96% | 28.95 | 221 / 230 |
kidney | 99% | 2194.89 | 88 / 89 | 97% | 38.53 | 873 / 901 |
brain | 95% | 3270.75 | 2521 / 2642 | 100% | 36.59 | 703 / 705 |
stomach | 97% | 2474.16 | 350 / 359 | 97% | 37.43 | 277 / 286 |
skin | 99% | 3602.77 | 1793 / 1809 | 91% | 40.59 | 429 / 472 |
pancreas | 89% | 1399.23 | 292 / 328 | 98% | 41.55 | 175 / 178 |
liver | 92% | 1413.90 | 208 / 226 | 92% | 23.92 | 374 / 406 |
blood vessel | 100% | 8231.55 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.64 | 1 / 1 |
adipose | 100% | 5586.49 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 4872.17 | 802 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2859.73 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 99% | 8753.57 | 849 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 27.65 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 83% | 24.59 | 24 / 29 |
peripheral blood | 79% | 2251.98 | 730 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 54% | 9.96 | 43 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0035865 | Biological process | cellular response to potassium ion |
GO_1904355 | Biological process | positive regulation of telomere capping |
GO_1900227 | Biological process | positive regulation of NLRP3 inflammasome complex assembly |
GO_0051225 | Biological process | spindle assembly |
GO_0007346 | Biological process | regulation of mitotic cell cycle |
GO_0051973 | Biological process | positive regulation of telomerase activity |
GO_0006468 | Biological process | protein phosphorylation |
GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
GO_0005874 | Cellular component | microtubule |
GO_0000922 | Cellular component | spindle pole |
GO_0005813 | Cellular component | centrosome |
GO_0005815 | Cellular component | microtubule organizing center |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0140677 | Molecular function | molecular function activator activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NEK7 |
Protein name | NEK6-subfamily protein kinase (EC 2.7.11.34) Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NIMA related kinase 7 |
Synonyms | |
Description | FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression . Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis . Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression . Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity . Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 . Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis . . |
Accessions | ENST00000367383.5 [Q8TDX7-2] F5H3U7 Q8TDX7 ENST00000538004.5 [Q8TDX7-1] ENST00000391974.3 C9J1H8 ENST00000367385.9 [Q8TDX7-1] ENST00000544035.5 F8WAG2 ENST00000442588.5 |