NEK7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0035865Biological processcellular response to potassium ion
GO_1904355Biological processpositive regulation of telomere capping
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0051225Biological processspindle assembly
GO_0007346Biological processregulation of mitotic cell cycle
GO_0051973Biological processpositive regulation of telomerase activity
GO_0006468Biological processprotein phosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0005815Cellular componentmicrotubule organizing center
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140677Molecular functionmolecular function activator activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEK7
Protein nameNEK6-subfamily protein kinase (EC 2.7.11.34)
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
NIMA related kinase 7
Synonyms
DescriptionFUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression . Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis . Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression . Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity . Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 . Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis . .

AccessionsENST00000367383.5 [Q8TDX7-2]
F5H3U7
Q8TDX7
ENST00000538004.5 [Q8TDX7-1]
ENST00000391974.3
C9J1H8
ENST00000367385.9 [Q8TDX7-1]
ENST00000544035.5
F8WAG2
ENST00000442588.5