NECTIN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902414Biological processprotein localization to cell junction
GO_0046718Biological processsymbiont entry into host cell
GO_0009566Biological processfertilization
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0060042Biological processretina morphogenesis in camera-type eye
GO_0002089Biological processlens morphogenesis in camera-type eye
GO_0061951Biological processestablishment of protein localization to plasma membrane
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0044291Cellular componentcell-cell contact zone
GO_0030425Cellular componentdendrite
GO_0005911Cellular componentcell-cell junction
GO_0043296Cellular componentapical junction complex
GO_0005912Cellular componentadherens junction
GO_0030424Cellular componentaxon
GO_0042803Molecular functionprotein homodimerization activity
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNECTIN3
Protein nameNectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Nectin cell adhesion molecule 3
SynonymsPVRL3
PRR3
DescriptionFUNCTION: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. .

AccessionsENST00000493615.5 [Q9NQS3-3]
H7C4L0
H7C5G5
C9JMW3
C9J795
C9IZE6
ENST00000491525.5
Q9NQS3
ENST00000319792.7 [Q9NQS3-2]
ENST00000485303.6 [Q9NQS3-1]
ENST00000461477.5
ENST00000486596.5
ENST00000481766.1
ENST00000485506.1