MTREX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006401Biological processRNA catabolic process
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000460Biological processmaturation of 5.8S rRNA
GO_0016076Biological processsnRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0031499Cellular componentTRAMP complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0003724Molecular functionRNA helicase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMTREX
Protein nameAlternative protein SKIV2L2
SKIV2L2 protein
Mtr4 exosome RNA helicase
Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)
SynonymsSKIV2L2
MTR4
DOB1
KIAA0052
DescriptionFUNCTION: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension . Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) . NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs . PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters . Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA . May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand . Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex . Plays a role in DNA damage response . .

AccessionsENST00000508716.1
H0Y8U3
ENST00000506750.5
D6REC7
Q3MHC9
P42285
ENST00000230640.10
L8E9T8
ENST00000505565.5
H0YAC4