Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 27% ± 9% | |
oligodendrocyte | 11 studies | 37% ± 14% | |
fibroblast | 10 studies | 24% ± 8% | |
astrocyte | 10 studies | 34% ± 16% | |
GABAergic neuron | 8 studies | 40% ± 21% | |
oligodendrocyte precursor cell | 8 studies | 34% ± 17% | |
epithelial cell | 7 studies | 32% ± 14% | |
adipocyte | 7 studies | 30% ± 6% | |
glutamatergic neuron | 6 studies | 49% ± 26% | |
microglial cell | 6 studies | 28% ± 10% | |
interneuron | 6 studies | 41% ± 23% | |
neuron | 5 studies | 39% ± 16% | |
B cell | 5 studies | 20% ± 3% | |
retinal rod cell | 5 studies | 20% ± 2% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 5% | |
macrophage | 5 studies | 28% ± 7% | |
pericyte | 5 studies | 24% ± 10% | |
smooth muscle cell | 5 studies | 21% ± 4% | |
amacrine cell | 4 studies | 21% ± 5% | |
retinal bipolar neuron | 4 studies | 19% ± 2% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
ciliated cell | 4 studies | 24% ± 4% | |
lymphocyte | 4 studies | 21% ± 6% | |
dendritic cell | 4 studies | 24% ± 7% | |
natural killer cell | 4 studies | 16% ± 1% | |
plasma cell | 3 studies | 30% ± 10% | |
retinal cone cell | 3 studies | 24% ± 3% | |
myeloid cell | 3 studies | 18% ± 2% | |
rod bipolar cell | 3 studies | 25% ± 10% | |
monocyte | 3 studies | 19% ± 3% | |
basal cell | 3 studies | 34% ± 13% | |
mast cell | 3 studies | 21% ± 3% | |
plasmacytoid dendritic cell | 3 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2932.72 | 1445 / 1445 | 100% | 27.24 | 183 / 183 |
breast | 100% | 3348.43 | 459 / 459 | 100% | 39.47 | 1117 / 1118 |
lung | 100% | 3049.32 | 577 / 578 | 100% | 28.02 | 1154 / 1155 |
intestine | 100% | 2997.67 | 966 / 966 | 100% | 30.99 | 525 / 527 |
ovary | 100% | 3534.56 | 180 / 180 | 99% | 17.05 | 427 / 430 |
stomach | 100% | 2390.74 | 359 / 359 | 99% | 29.02 | 284 / 286 |
bladder | 100% | 3262.71 | 21 / 21 | 99% | 26.82 | 500 / 504 |
prostate | 100% | 2964.70 | 245 / 245 | 99% | 26.74 | 498 / 502 |
brain | 99% | 1975.38 | 2617 / 2642 | 100% | 28.57 | 705 / 705 |
uterus | 100% | 3802.16 | 170 / 170 | 99% | 28.41 | 454 / 459 |
pancreas | 100% | 2018.56 | 328 / 328 | 99% | 25.33 | 176 / 178 |
thymus | 100% | 3295.21 | 653 / 653 | 99% | 29.52 | 598 / 605 |
kidney | 100% | 2225.79 | 89 / 89 | 98% | 27.85 | 882 / 901 |
adrenal gland | 100% | 3099.17 | 258 / 258 | 98% | 27.49 | 225 / 230 |
skin | 100% | 3792.87 | 1808 / 1809 | 97% | 31.89 | 456 / 472 |
liver | 100% | 1594.05 | 226 / 226 | 95% | 16.74 | 385 / 406 |
adipose | 100% | 3480.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3764.10 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.34 | 29 / 29 |
muscle | 100% | 3741.88 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2694.85 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 34.08 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.33 | 1 / 1 |
heart | 97% | 2379.84 | 835 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 17.89 | 72 / 80 |
peripheral blood | 72% | 1748.88 | 670 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006974 | Biological process | DNA damage response |
GO_0006401 | Biological process | RNA catabolic process |
GO_0000398 | Biological process | mRNA splicing, via spliceosome |
GO_0000460 | Biological process | maturation of 5.8S rRNA |
GO_0016076 | Biological process | snRNA catabolic process |
GO_0006364 | Biological process | rRNA processing |
GO_0005730 | Cellular component | nucleolus |
GO_0000178 | Cellular component | exosome (RNase complex) |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0031499 | Cellular component | TRAMP complex |
GO_0071013 | Cellular component | catalytic step 2 spliceosome |
GO_0000176 | Cellular component | nuclear exosome (RNase complex) |
GO_0005634 | Cellular component | nucleus |
GO_0003724 | Molecular function | RNA helicase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | MTREX |
Protein name | Alternative protein SKIV2L2 SKIV2L2 protein Mtr4 exosome RNA helicase Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) |
Synonyms | SKIV2L2 MTR4 DOB1 KIAA0052 |
Description | FUNCTION: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension . Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) . NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs . PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters . Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA . May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand . Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex . Plays a role in DNA damage response . . |
Accessions | ENST00000508716.1 H0Y8U3 ENST00000506750.5 D6REC7 Q3MHC9 P42285 ENST00000230640.10 L8E9T8 ENST00000505565.5 H0YAC4 |