Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 37% ± 13% | |
fibroblast | 14 studies | 37% ± 12% | |
glutamatergic neuron | 12 studies | 48% ± 25% | |
astrocyte | 12 studies | 38% ± 14% | |
pericyte | 11 studies | 38% ± 17% | |
oligodendrocyte | 11 studies | 32% ± 11% | |
GABAergic neuron | 10 studies | 46% ± 23% | |
dendritic cell | 10 studies | 37% ± 12% | |
macrophage | 10 studies | 41% ± 15% | |
adipocyte | 9 studies | 30% ± 12% | |
microglial cell | 9 studies | 41% ± 12% | |
mast cell | 8 studies | 26% ± 7% | |
smooth muscle cell | 8 studies | 37% ± 13% | |
myeloid cell | 8 studies | 32% ± 16% | |
oligodendrocyte precursor cell | 8 studies | 37% ± 15% | |
T cell | 7 studies | 24% ± 7% | |
endothelial cell of lymphatic vessel | 7 studies | 39% ± 11% | |
cardiac muscle cell | 5 studies | 29% ± 7% | |
monocyte | 5 studies | 42% ± 10% | |
basal cell | 5 studies | 48% ± 25% | |
type I pneumocyte | 5 studies | 39% ± 9% | |
type II pneumocyte | 5 studies | 35% ± 8% | |
interneuron | 5 studies | 55% ± 22% | |
classical monocyte | 4 studies | 19% ± 2% | |
neuron | 4 studies | 52% ± 14% | |
epithelial cell | 4 studies | 46% ± 25% | |
B cell | 4 studies | 25% ± 6% | |
CD4-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
mesothelial cell | 4 studies | 33% ± 7% | |
Mueller cell | 4 studies | 25% ± 8% | |
amacrine cell | 4 studies | 23% ± 3% | |
retina horizontal cell | 4 studies | 23% ± 6% | |
retinal cone cell | 4 studies | 63% ± 9% | |
retinal rod cell | 4 studies | 38% ± 8% | |
myofibroblast cell | 4 studies | 32% ± 15% | |
club cell | 4 studies | 29% ± 4% | |
mononuclear phagocyte | 3 studies | 32% ± 12% | |
vein endothelial cell | 3 studies | 40% ± 19% | |
GABAergic amacrine cell | 3 studies | 28% ± 2% | |
glycinergic amacrine cell | 3 studies | 22% ± 2% | |
abnormal cell | 3 studies | 41% ± 17% | |
endothelial cell of vascular tree | 3 studies | 39% ± 20% | |
hepatocyte | 3 studies | 44% ± 27% | |
connective tissue cell | 3 studies | 27% ± 9% | |
ependymal cell | 3 studies | 41% ± 10% | |
alveolar macrophage | 3 studies | 43% ± 9% | |
capillary endothelial cell | 3 studies | 23% ± 7% | |
ciliated cell | 3 studies | 29% ± 5% | |
natural killer cell | 3 studies | 24% ± 4% | |
respiratory goblet cell | 3 studies | 37% ± 13% | |
lymphocyte | 3 studies | 41% ± 6% | |
muscle cell | 3 studies | 33% ± 16% | |
granule cell | 3 studies | 37% ± 12% | |
mural cell | 3 studies | 34% ± 12% | |
mucus secreting cell | 3 studies | 29% ± 8% | |
regulatory T cell | 3 studies | 21% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3664.86 | 1445 / 1445 | 100% | 26.29 | 183 / 183 |
prostate | 100% | 3760.49 | 245 / 245 | 100% | 19.40 | 502 / 502 |
skin | 100% | 4088.61 | 1809 / 1809 | 100% | 32.79 | 472 / 472 |
stomach | 100% | 2875.55 | 359 / 359 | 100% | 20.72 | 286 / 286 |
thymus | 100% | 4510.27 | 653 / 653 | 100% | 24.34 | 605 / 605 |
uterus | 100% | 6020.23 | 170 / 170 | 100% | 25.33 | 459 / 459 |
lung | 100% | 4524.28 | 578 / 578 | 100% | 24.27 | 1153 / 1155 |
intestine | 100% | 3612.67 | 966 / 966 | 100% | 19.32 | 526 / 527 |
kidney | 100% | 2374.79 | 89 / 89 | 100% | 19.94 | 898 / 901 |
bladder | 100% | 4327.43 | 21 / 21 | 100% | 21.49 | 502 / 504 |
ovary | 100% | 3882.79 | 180 / 180 | 100% | 18.37 | 428 / 430 |
breast | 100% | 4170.70 | 459 / 459 | 99% | 24.23 | 1112 / 1118 |
pancreas | 98% | 1672.38 | 323 / 328 | 100% | 29.83 | 178 / 178 |
brain | 98% | 2537.19 | 2580 / 2642 | 100% | 29.36 | 705 / 705 |
adrenal gland | 100% | 2645.54 | 258 / 258 | 97% | 14.89 | 222 / 230 |
liver | 92% | 1102.55 | 207 / 226 | 95% | 11.98 | 386 / 406 |
adipose | 100% | 3837.95 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5364.93 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 27.91 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 48.66 | 29 / 29 |
spleen | 100% | 5195.19 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 30.10 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 44.98 | 1 / 1 |
heart | 99% | 2407.39 | 856 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4698.89 | 918 / 929 | 0% | 0 | 0 / 0 |
muscle | 99% | 1618.63 | 793 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_1902895 | Biological process | positive regulation of miRNA transcription |
GO_0044319 | Biological process | wound healing, spreading of cells |
GO_0051145 | Biological process | smooth muscle cell differentiation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0043522 | Molecular function | leucine zipper domain binding |
GO_0003785 | Molecular function | actin monomer binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | MRTFA |
Protein name | Alternative protein MKL1 Myocardin related transcription factor A MKL1 protein Mkl1 variant 1 Mkl1_S (Myocardin related transcription factor A) Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) Phosphatase and actin regulator |
Synonyms | mkl1 MAL KIAA1438 hCG_41119 MKL1 |
Description | FUNCTION: Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration . The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. . |
Accessions | ENST00000402042.7 ENST00000402630.5 ENST00000699988.1 ENST00000355630.10 ENST00000422851.1 L8E8L9 ENST00000651694.1 A0A8V8TPQ1 Q29R68 B0QY84 A0A499FIJ6 A0A087X287 A0A494C1G6 ENST00000407029.7 A0A087WU73 Q969V6 B0QY74 ENST00000463769.7 B0QY83 A4FUJ8 A0A669KBG1 ENST00000651595.2 A0A494C0Z8 W0Z7M9 A0A494BZX7 ENST00000673719.1 ENST00000620651.4 ENST00000652095.2 ENST00000614754.4 |