MRTFA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030036Biological processactin cytoskeleton organization
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0044319Biological processwound healing, spreading of cells
GO_0051145Biological processsmooth muscle cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0043522Molecular functionleucine zipper domain binding
GO_0003785Molecular functionactin monomer binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameMRTFA
Protein nameAlternative protein MKL1
Myocardin related transcription factor A
MKL1 protein
Mkl1 variant 1 Mkl1_S (Myocardin related transcription factor A)
Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)
Phosphatase and actin regulator
Synonymsmkl1
MAL
KIAA1438
hCG_41119
MKL1
DescriptionFUNCTION: Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration . The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. .

AccessionsENST00000402042.7
ENST00000402630.5
ENST00000699988.1
ENST00000355630.10
ENST00000422851.1
L8E8L9
ENST00000651694.1
A0A8V8TPQ1
Q29R68
B0QY84
A0A499FIJ6
A0A087X287
A0A494C1G6
ENST00000407029.7
A0A087WU73
Q969V6
B0QY74
ENST00000463769.7
B0QY83
A4FUJ8
A0A669KBG1
ENST00000651595.2
A0A494C0Z8
W0Z7M9
A0A494BZX7
ENST00000673719.1
ENST00000620651.4
ENST00000652095.2
ENST00000614754.4