MKNK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0030097Biological processhemopoiesis
GO_0006417Biological processregulation of translation
GO_0035556Biological processintracellular signal transduction
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0071243Biological processcellular response to arsenic-containing substance
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0009931Molecular functioncalcium-dependent protein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMKNK2
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
MAPK interacting serine/threonine kinase 2
SynonymsGPRK7
MNK2
DescriptionFUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. .

AccessionsQ9NV89
K7ELN0
ENST00000309340.11 [Q9HBH9-2]
ENST00000591588.1
K7EJ98
ENST00000250896.9 [Q9HBH9-1]
K7ELG3
K7EK27
ENST00000588014.5
K7EMP5
ENST00000589534.2
ENST00000589441.5
ENST00000591142.5
ENST00000589509.5
ENST00000586828.5
K7EIN7
Q9HBH9