METTL5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	13 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	18% ± 4%	Explore
CD4-positive, alpha-beta T cell	10 studies	23% ± 8%	Explore
regulatory T cell	10 studies	21% ± 5%	Explore
natural killer cell	9 studies	22% ± 5%	Explore
basal cell	8 studies	29% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
B cell	7 studies	20% ± 4%	Explore
endothelial cell	7 studies	27% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
smooth muscle cell	6 studies	19% ± 4%	Explore
epithelial cell	6 studies	42% ± 17%	Explore
ciliated cell	6 studies	35% ± 16%	Explore
plasma cell	5 studies	28% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 6%	Explore
T cell	5 studies	18% ± 3%	Explore
naive B cell	5 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
erythroblast	5 studies	33% ± 13%	Explore
pericyte	5 studies	21% ± 1%	Explore
abnormal cell	5 studies	22% ± 4%	Explore
gamma-delta T cell	5 studies	25% ± 15%	Explore
memory B cell	5 studies	20% ± 4%	Explore
mucosal invariant T cell	5 studies	19% ± 3%	Explore
plasmablast	4 studies	44% ± 19%	Explore
pancreatic A cell	4 studies	32% ± 9%	Explore
conventional dendritic cell	4 studies	30% ± 12%	Explore
fibroblast	4 studies	26% ± 9%	Explore
endothelial cell of vascular tree	4 studies	19% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 6%	Explore
hematopoietic precursor cell	3 studies	30% ± 8%	Explore
type B pancreatic cell	3 studies	42% ± 2%	Explore
classical monocyte	3 studies	23% ± 8%	Explore
non-classical monocyte	3 studies	23% ± 2%	Explore
macrophage	3 studies	30% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
GABAergic neuron	3 studies	27% ± 3%	Explore
glutamatergic neuron	3 studies	35% ± 4%	Explore
goblet cell	3 studies	24% ± 5%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	22% ± 5%	Explore
lung	5 studies	30% ± 18%	Explore
brain	4 studies	24% ± 5%	Explore
pancreas	3 studies	38% ± 6%	Explore
liver	3 studies	31% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1488.87	1445 / 1445	100%	26.97	183 / 183
ovary	100%	861.26	180 / 180	100%	34.37	430 / 430
pancreas	100%	990.77	328 / 328	100%	24.19	178 / 178
stomach	100%	1154.83	359 / 359	100%	32.31	286 / 286
uterus	100%	1059.38	170 / 170	100%	31.01	459 / 459
thymus	100%	1095.90	653 / 653	100%	24.58	604 / 605
brain	100%	1135.00	2637 / 2642	100%	26.86	705 / 705
intestine	100%	1491.40	966 / 966	100%	34.01	526 / 527
breast	100%	1526.29	459 / 459	100%	28.74	1115 / 1118
bladder	100%	1449.81	21 / 21	100%	29.58	502 / 504
prostate	100%	1184.80	245 / 245	100%	24.93	500 / 502
lung	99%	886.04	575 / 578	100%	28.15	1155 / 1155
liver	100%	701.46	225 / 226	100%	19.27	405 / 406
skin	100%	1243.03	1807 / 1809	99%	21.64	468 / 472
kidney	100%	1151.49	89 / 89	99%	20.73	892 / 901
adrenal gland	100%	1324.61	258 / 258	98%	20.90	226 / 230
adipose	100%	1577.59	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2075.36	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	28.92	29 / 29
spleen	100%	919.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.58	45 / 45
ureter	0%	0	0 / 0	100%	15.96	1 / 1
muscle	100%	1263.88	802 / 803	0%	0	0 / 0
heart	98%	1236.64	847 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	14.73	76 / 80
peripheral blood	38%	621.77	353 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048863	Biological process	stem cell differentiation
GO_0031167	Biological process	rRNA methylation
GO_0006364	Biological process	rRNA processing
GO_0045727	Biological process	positive regulation of translation
GO_0042995	Cellular component	cell projection
GO_0005730	Cellular component	nucleolus
GO_0098793	Cellular component	presynapse
GO_0005829	Cellular component	cytosol
GO_0098794	Cellular component	postsynapse
GO_0001650	Cellular component	fibrillar center
GO_0005634	Cellular component	nucleus
GO_1904047	Molecular function	S-adenosyl-L-methionine binding
GO_0008988	Molecular function	rRNA (adenine-N6-)-methyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0003676	Molecular function	nucleic acid binding

IV. Literature review

[source]

Gene name	METTL5
Protein name	Methyltransferase-like protein 5 rRNA N6-adenosine-methyltransferase METTL5 (EC 2.1.1.-) (Methyltransferase-like protein 5) Methyltransferase 5, N6-adenosine
Synonyms	HSPC133 DC3 hCG_2005083
Description	FUNCTION: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA . N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation . .
Accessions	ENST00000410097.5 F5H4E8 ENST00000392640.6 ENST00000538491.1 E7EMN2 B8ZZE3 ENST00000442181.5 ENST00000409837.5 B8ZZY8 ENST00000409340.5 B8ZZC8 Q9NRN9 ENST00000308099.7 H0YFV5 ENST00000537825.5 H7C0M7 ENST00000409965.5 ENST00000260953.10

METTL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review