MCRIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	23% ± 7%	Explore
fibroblast	19 studies	27% ± 10%	Explore
endothelial cell	18 studies	25% ± 7%	Explore
smooth muscle cell	16 studies	29% ± 9%	Explore
pericyte	15 studies	26% ± 8%	Explore
macrophage	12 studies	24% ± 9%	Explore
endothelial cell of lymphatic vessel	10 studies	27% ± 9%	Explore
non-classical monocyte	9 studies	29% ± 14%	Explore
CD8-positive, alpha-beta T cell	9 studies	23% ± 6%	Explore
gamma-delta T cell	9 studies	23% ± 12%	Explore
B cell	8 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	24% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	25% ± 5%	Explore
mature NK T cell	8 studies	21% ± 6%	Explore
connective tissue cell	8 studies	32% ± 9%	Explore
T cell	8 studies	19% ± 3%	Explore
myofibroblast cell	7 studies	32% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	22% ± 7%	Explore
endothelial cell of artery	6 studies	24% ± 8%	Explore
capillary endothelial cell	6 studies	20% ± 6%	Explore
classical monocyte	5 studies	28% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 6%	Explore
neuron	5 studies	37% ± 17%	Explore
regulatory T cell	5 studies	18% ± 3%	Explore
hematopoietic precursor cell	4 studies	33% ± 14%	Explore
mesothelial cell	4 studies	29% ± 6%	Explore
vein endothelial cell	4 studies	22% ± 6%	Explore
retinal ganglion cell	4 studies	50% ± 28%	Explore
mucosal invariant T cell	4 studies	16% ± 0%	Explore
precursor B cell	4 studies	24% ± 6%	Explore
amacrine cell	4 studies	36% ± 17%	Explore
ciliated cell	4 studies	24% ± 4%	Explore
endothelial cell of vascular tree	4 studies	20% ± 4%	Explore
dendritic cell	4 studies	33% ± 15%	Explore
abnormal cell	4 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	16% ± 0%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
conventional dendritic cell	3 studies	37% ± 7%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
monocyte	3 studies	25% ± 14%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 4%	Explore
neural crest cell	3 studies	35% ± 6%	Explore
naive B cell	3 studies	20% ± 2%	Explore
lymphocyte	3 studies	24% ± 5%	Explore
myeloid cell	3 studies	30% ± 9%	Explore
epithelial cell	3 studies	35% ± 19%	Explore
type I pneumocyte	3 studies	23% ± 6%	Explore
retinal rod cell	3 studies	21% ± 5%	Explore
Mueller cell	3 studies	26% ± 6%	Explore
basal cell	3 studies	24% ± 3%	Explore
plasmacytoid dendritic cell	3 studies	23% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	23% ± 9%	Explore
lung	7 studies	24% ± 7%	Explore
eye	4 studies	27% ± 9%	Explore
kidney	3 studies	19% ± 4%	Explore
intestine	3 studies	19% ± 3%	Explore
bone marrow	3 studies	16% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	4374.68	180 / 180	100%	77.33	430 / 430
thymus	100%	4473.26	653 / 653	100%	95.70	605 / 605
brain	100%	5403.03	2640 / 2642	100%	134.05	705 / 705
pancreas	100%	2676.97	327 / 328	100%	66.88	178 / 178
prostate	100%	5811.72	245 / 245	99%	84.30	498 / 502
skin	99%	2634.55	1798 / 1809	99%	115.50	469 / 472
adrenal gland	100%	3405.02	258 / 258	99%	67.22	227 / 230
breast	100%	4331.17	459 / 459	98%	74.94	1099 / 1118
uterus	100%	5328.62	170 / 170	98%	76.97	448 / 459
bladder	100%	5208.33	21 / 21	97%	73.27	491 / 504
kidney	100%	4330.36	89 / 89	97%	55.19	875 / 901
liver	97%	2106.52	219 / 226	98%	64.51	398 / 406
lung	100%	3979.58	577 / 578	93%	51.60	1078 / 1155
intestine	100%	4676.06	965 / 966	91%	34.56	482 / 527
stomach	100%	2862.09	358 / 359	81%	29.86	233 / 286
esophagus	97%	4208.26	1405 / 1445	65%	16.26	119 / 183
adipose	100%	4471.77	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	138.19	80 / 80
lymph node	0%	0	0 / 0	100%	99.59	29 / 29
spleen	100%	4161.97	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	82.88	1 / 1
blood vessel	100%	5563.71	1334 / 1335	0%	0	0 / 0
heart	100%	4030.24	860 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	36.83	44 / 45
peripheral blood	98%	2417.78	906 / 929	0%	0	0 / 0
muscle	92%	1378.03	740 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010717	Biological process	regulation of epithelial to mesenchymal transition
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MCRIP1
Protein name	Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) HCG1818442, isoform CRA_a (MAPK regulated corepressor interacting protein 1) MAPK regulated corepressor interacting protein 1
Synonyms	GRAN2 hCG_1818442 FAM195B
Description	FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition . .
Accessions	I3L4Q0 ENST00000457257.5 I3L3A7 ENST00000574190.5 ENST00000576431.5 ENST00000576730.5 ENST00000538396.5 ENST00000673154.1 ENST00000570507.5 ENST00000455127.7 ENST00000672501.1 ENST00000576679.1 ENST00000673369.1 ENST00000575061.2 ENST00000572645.5 I3L3C1 I3L2L5 ENST00000573478.5 ENST00000672201.1 I3L317 C9JLW8

MCRIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review